Jabbari-Azad Farahzad, Khoshkhui Maryam, Khalighi Negar, Mohammadi Mojgan, Emadzadeh Maryam, Aliabadi Mehraneh Movahedi
Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Email:
Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Qatar Med J. 2023 Nov 26;2023(2):21. doi: 10.5339/qmj.2023.sqac.21. eCollection 2023.
Propolis has an anti-inflammatory effect induced by inhibiting cyclooxygenase, subsequent inhibition of prostaglandin and nitric oxide synthesis, reduction of inflammatory cytokines, and eventually immunosuppressive activity [1-3]. This study aims to evaluate the impact of propolis on clinical features and specific IgE levels against salsola in perennial allergic rhinitis patients. Thirty patients diagnosed with perennial allergic rhinitis with salsola-positive skin prick test were enrolled in this randomized controlled clinical trial and divided into two groups. The intervention group received the propolis (200 mg per day), and the control group received a placebo for four months, besides intranasal corticosteroids. At baseline and the end of the intervention, the level of Salsola-specific IgE was measured by the RAST method. To assess the propolis effect on the quality of life and disease severity, miniRQLQ and SNOT22 questionnaires were completed by patients before and after the intervention. According to Table 1, Serum IgE level showed decreasing changes (-0.057) despite increasing changes in the control group (1.039). However, these differences were not statistically significant (P = 0.967). Based on the miniRQLQ questionnaire, quality of life improved in both groups without any significant difference (P = 0.930). According to the SNOT-22 questionnaire, both groups' nasal and sinus problems decreased significantly. However, the intervention type did not affect this decrease and was observed over time in both groups (P> 0.05). Propolis supplementation did not significantly affect various laboratory parameters, clinical symptoms, and quality of life of patients with allergic rhinitis.
蜂胶具有抗炎作用，其通过抑制环氧化酶、随后抑制前列腺素和一氧化氮的合成、减少炎性细胞因子，并最终产生免疫抑制活性[1-3]。本研究旨在评估蜂胶对常年性变应性鼻炎患者临床特征及针对猪毛菜的特异性IgE水平的影响。30例经诊断为常年性变应性鼻炎且皮肤点刺试验对猪毛菜呈阳性的患者纳入了这项随机对照临床试验，并分为两组。干预组接受蜂胶（每日200毫克），对照组除鼻用糖皮质激素外，接受安慰剂治疗四个月。在基线期和干预结束时，采用放射性变应原吸附试验（RAST）法测量猪毛菜特异性IgE水平。为评估蜂胶对生活质量和疾病严重程度的影响，患者在干预前后完成了小型鼻炎生活质量问卷（miniRQLQ）和鼻窦鼻症状测试22项问卷（SNOT22）。根据表1，尽管对照组呈上升变化（1.039），但血清IgE水平呈下降变化（-0.057）。然而，这些差异无统计学意义（P = 0.967）。根据miniRQLQ问卷，两组的生活质量均有所改善，且无显著差异（P = 0.930）。根据SNOT-22问卷，两组的鼻和鼻窦问题均显著减少。然而，干预类型并未影响这种减少，且两组均随时间观察到这种情况（P>0.05）。补充蜂胶对变应性鼻炎患者的各项实验室参数、临床症状和生活质量均无显著影响。
