De Scalzi M, De Leonardis V, Citi S, Cinelli P
Clin Cardiol. 1986 Nov;9(11):545-9. doi: 10.1002/clc.4960091104.
It has been suggested that systolic time intervals (STI) can be used to monitor the cardiac effects of antihypertensive treatments and also to evaluate hypertensive patients. STI changes observed in hypertensives have been ascribed to myocardial disease, although they could be due to the existence of a relationship between STI and blood pressure. A group of 37 subjects (18 normotensives and 19 hypertensives) with no signs of heart failure and left ventricular dysfunction were studied to examine the relationship of STI to blood pressure. Pacing with an external battery pulse generator was performed at the rate of 95 beats/min in order to eliminate differences in heart rate. STI were measured from good quality high speed (100 mm/s) recordings and the average value of 10 consecutive cardiac cycles was used for statistical analysis. Normal subjects showed significantly lower values of pre-ejection period (PEP), electromechanical systole (QS2), and pre-ejection period/left ventricular ejection time ratio (PEP/LVET). Moreover, a significant inverse relationship between diastolic pressure and LVET and significant direct relationships between diastolic pressure and PEP, systolic pressure and PEP, diastolic pressure and PEP/LVET, and between systolic pressure and PEP/LVET were demonstrated. We suggest to consider the relation of STI to blood pressure to provide regression equations to best appreciate and use STI.
有人提出，收缩期时间间期（STI）可用于监测抗高血压治疗对心脏的影响，也可用于评估高血压患者。高血压患者中观察到的STI变化被归因于心肌疾病，尽管这些变化可能是由于STI与血压之间存在某种关系。对一组37名无心力衰竭和左心室功能障碍迹象的受试者（18名血压正常者和19名高血压患者）进行了研究，以检查STI与血压的关系。使用外部电池脉冲发生器以95次/分钟的速率进行起搏，以消除心率差异。从高质量的高速（100毫米/秒）记录中测量STI，并将10个连续心动周期的平均值用于统计分析。正常受试者的射血前期（PEP）、机电收缩期（QS2）和射血前期/左心室射血时间比值（PEP/LVET）值明显较低。此外，还证明舒张压与LVET之间存在显著的负相关关系，舒张压与PEP、收缩压与PEP、舒张压与PEP/LVET以及收缩压与PEP/LVET之间存在显著的正相关关系。我们建议考虑STI与血压的关系，以提供回归方程，以便更好地理解和使用STI。
