Kleinrok Z, Rajtar G
Acta Physiol Pol. 1979 Mar-Apr;30(2):289-94.
Effects of atropine and toxogonine on metabolism of the isolated rat liver changed by diisopropylofluorophosphate (DFP). Acta Physiol., 1979, 30 (2): 289--294. In the investigations on isolated rat liver it was found that DFP in a dose corresponding to 1/2 of the LD50 inhibited the activity of AChE, caused hypoglycaemia, decreased the level or pyruvate and increased that of lactate and hepatic glycogen, and increased the activity of transaminases. Atropine and toxogonine administered separately in a concentration of 0.5 mg/100 ml reduced the pyruvate level without changing the other parameters. Administered together with DFP they reactivated the activity of AChE, abolished hypoglycaemia and antagonized in part the effect of DFP on lactate level and transaminase activity.
阿托品和氯磷定对由二异丙基氟磷酸酯（DFP）引起变化的离体大鼠肝脏代谢的影响。《生理学学报》，1979年，30（2）：289 - 294。在对离体大鼠肝脏的研究中发现，剂量相当于半数致死量一半的DFP抑制乙酰胆碱酯酶（AChE）的活性，引起低血糖，降低丙酮酸水平，升高乳酸和肝糖原水平，并增加转氨酶的活性。以0.5毫克/100毫升的浓度单独给予阿托品和氯磷定可降低丙酮酸水平，而不改变其他参数。与DFP一起给予时，它们可使AChE的活性重新激活，消除低血糖，并部分拮抗DFP对乳酸水平和转氨酶活性的影响。
