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线粒体类核和真核细胞核中的多相分离。

Multi-phase separation in mitochondrial nucleoids and eukaryotic nuclei.

作者信息

Long Qi, Zhou Yanshuang, Guo Jingyi, Wu Hao, Liu Xingguo

机构信息

CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Guangzhou Medical University; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.

Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, China-New Zealand Joint Laboratory on Biomedicine and Health, CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine, Institute for Stem Cell and Regeneration, Institute for Stem Cell and Regeneration, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.

出版信息

Biophys Rep. 2023 Jun 30;9(3):113-119. doi: 10.52601/bpr.2023.220018.

DOI:10.52601/bpr.2023.220018
PMID:38028151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10648231/
Abstract

In mammalian cells, besides nuclei, mitochondria are the only semi-autonomous organelles possessing own DNA organized in the form of nucleoids. While eukaryotic nuclear DNA compaction, chromatin compartmentalization and transcription are regulated by phase separation, our recent work proposed a model of mitochondrial nucleoid self-assembly and transcriptional regulation by multi-phase separation. Herein, we summarized the phase separation both in the nucleus and mitochondrial nucleoids, and did a comparison of the organization and activity regulating, which would provide new insight into the understanding of both architecture and genetics of nucleus and mitochondrial nucleoids.

摘要

在哺乳动物细胞中，除细胞核外，线粒体是唯一具有以类核形式组织的自身DNA的半自主细胞器。虽然真核细胞核DNA的压缩、染色质区室化和转录受相分离调控，但我们最近的工作提出了一种通过多相分离进行线粒体类核自组装和转录调控的模型。在此，我们总结了细胞核和线粒体类核中的相分离，并对其组织和活性调控进行了比较，这将为理解细胞核和线粒体类核的结构和遗传学提供新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23b2/10648231/829fbebd7173/br-9-3-113-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23b2/10648231/1867ce81b719/br-9-3-113-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23b2/10648231/829fbebd7173/br-9-3-113-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23b2/10648231/1867ce81b719/br-9-3-113-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23b2/10648231/829fbebd7173/br-9-3-113-2.jpg

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本文引用的文献

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Nat Struct Mol Biol. 2021 Nov;28(11):900-908. doi: 10.1038/s41594-021-00671-w. Epub 2021 Oct 28.
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Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation.增强子 RNA m6A 甲基化促进转录凝聚体的形成和基因激活。
Mol Cell. 2021 Aug 19;81(16):3368-3385.e9. doi: 10.1016/j.molcel.2021.07.024. Epub 2021 Aug 9.
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N-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.
mRNA 上的 N6-甲基腺苷有助于形成一个液-液相分离的核体，从而抑制髓系白血病的分化。
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Self-assembly of multi-component mitochondrial nucleoids via phase separation.通过相分离实现多组分线粒体核小体的自组装。
EMBO J. 2021 Mar 15;40(6):e107165. doi: 10.15252/embj.2020107165. Epub 2021 Feb 23.
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RNA-Mediated Feedback Control of Transcriptional Condensates.RNA 介导的转录凝聚物反馈控制。
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Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells.体外和活细胞中浓缩染色质表现为介观固体。
Cell. 2020 Dec 23;183(7):1772-1784.e13. doi: 10.1016/j.cell.2020.11.027. Epub 2020 Dec 15.
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The Self-Organizing Genome: Principles of Genome Architecture and Function.自组织基因组：基因组结构与功能原理。
Cell. 2020 Oct 1;183(1):28-45. doi: 10.1016/j.cell.2020.09.014. Epub 2020 Sep 24.
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The nucleolus as a multiphase liquid condensate.核仁作为一个多相的液态凝聚物。
Nat Rev Mol Cell Biol. 2021 Mar;22(3):165-182. doi: 10.1038/s41580-020-0272-6. Epub 2020 Sep 1.
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Biomolecular Condensates in the Nucleus.核内生物分子凝聚物。
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Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18540-18549. doi: 10.1073/pnas.2005019117. Epub 2020 Jul 16.