Center for Infectious Diseases, Nara Medical University.
Department of General Internal Medicine and Infectious Diseases, Nara Prefecture Seiwa Medical Center.
Med Mycol J. 2023;64(4):99-102. doi: 10.3314/mmj.23-00004.
Aspergillus udagawae is a cryptic species of Aspergillus section Fumigati. Here, we report a case of canaliculitis with isolated A. udagawae. Fungal canaliculitis is a rare lacrimal disease, and its clinical features are poorly understood. The causative fungus was initially misclassified as Aspergillus thermomutatus by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) but was finally identified as A. udagawae by β-tubulin genetic analysis. The patient showed rapid improvement and did not experience relapse after drainage alone, without antifungal therapy. A. udagawae has low virulence, which may be related to the minimally invasive nature of the infection.
乌达卡沃曲霉是散囊菌科烟曲霉菌组的一个隐种。本文报道了一例孤立性乌达卡沃曲霉引起的泪小管炎。真菌性泪小管炎是一种罕见的泪器疾病，其临床特征尚未完全清楚。最初，通过基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF MS）将致病真菌错误地鉴定为嗜热毁丝霉，但通过β-微管基因分析最终鉴定为乌达卡沃曲霉。患者在单纯引流后迅速改善，且未经历复发，未接受抗真菌治疗。乌达卡沃曲霉的毒力较低，这可能与感染的微创性质有关。
