头孢孟多在厌氧菌感染中的治疗作用。
Cefamandole therapy in anaerobic infections.
作者信息
Greenberg R N, Scalcini M C, Sanders C V, Lewis A C
出版信息
Antimicrob Agents Chemother. 1979 Mar;15(3):337-41. doi: 10.1128/AAC.15.3.337.
Thirty-one adult patients with infections due to anaerobic bacteria were treated with cefamandole. Bacteroides fragilis group (17) and Bacteroides melaninogenicus (13) were the most frequent anaerobes isolated. Duration of therapy varied from 2 to 49 days. Results were judged satisfactory in 26 cases, and unsatisfactory in 1 case. Four cases could not be evaluated. Adverse reactions occurred in 16 patients and included positive direct Coombs' test without hemolysis, transient liver function abnormalities, phlebitis, reversible neutropenia, fever, eosinophilia, and toxic epidermal necrolysis. The more significant reactions were associated with prolonged therapy. None was lethal. These data suggest that cefamandole is effective in treatment of most anaerobic infections.
31例成年厌氧菌感染患者接受了头孢孟多治疗。脆弱拟杆菌属（17例）和产黑色素拟杆菌（13例）是最常分离出的厌氧菌。治疗时间从2天到49天不等。26例患者治疗结果判定为满意，1例不满意。4例无法评估。16例患者出现不良反应，包括直接抗人球蛋白试验阳性但无溶血、短暂肝功能异常、静脉炎、可逆性中性粒细胞减少、发热、嗜酸性粒细胞增多和中毒性表皮坏死松解症。较严重的反应与治疗时间延长有关。无一例致死。这些数据表明头孢孟多对大多数厌氧菌感染有效。
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