Ernst E C, Berger S, Barza M, Jacobus N V, Tally F P
Antimicrob Agents Chemother. 1976 May;9(5):852-5. doi: 10.1128/AAC.9.5.852.
The activity of cefamandole was comparable to that of cephalothin, cefazolin, and cephaloridine against Staphylococcus aureus, Streptococcus pyogenes, and Diplococcus pneumoniae. In contrast, cefamandole was considerably more active than cephalothin, cefazolin, or cephaloridine against gram-negative facultative bacilli, including Haemophilus influenzae, the most striking disparities being noted with indole-positive Proteus and Enterobacter. Bacteroides fragilis was more susceptible to cefoxitin than to cefamandole or cefazolin (median minimal inhibitory concentration, approximately 8, 32, and 32 mug/ml, respectively); cephalothin exhibited still less activity against this species. The majority of other anaerobes were inhibited by relatively low concentrations of all four cephalosporins. The results indicate a potentially valuable role for cefamandole against facultative gram-negative bacilli, including H. influenzae, but no exceptional activity against anaerobes.
头孢孟多对金黄色葡萄球菌、化脓性链球菌和肺炎双球菌的活性与头孢噻吩、头孢唑林和头孢嘧啶相当。相比之下，头孢孟多对革兰氏阴性兼性杆菌，包括流感嗜血杆菌，比头孢噻吩、头孢唑林或头孢嘧啶的活性要强得多，在吲哚阳性变形杆菌和肠杆菌中观察到的差异最为显著。脆弱拟杆菌对头孢西丁比对头孢孟多或头孢唑林更敏感（中位最小抑菌浓度分别约为8、32和32μg/ml）；头孢噻吩对该菌的活性更低。大多数其他厌氧菌对所有四种头孢菌素的相对低浓度敏感。结果表明头孢孟多对包括流感嗜血杆菌在内的革兰氏阴性兼性杆菌有潜在的重要作用，但对厌氧菌没有特别的活性。
