染色质调节因子 Eaf3p 作为一个反式作用因子调节 中的氮代谢。
Chromatin regulator Eaf3p regulates nitrogen metabolism in as a trans-acting factor.
机构信息
College of Biological and Food Engineering, Anhui Polytechnic University, Wuhu, China.
Engineering Research Center of Ministry of Education on Food Synthetic Biotechnology, Jiangnan University, Wuxi, Jiangsu, China.
出版信息
Appl Environ Microbiol. 2023 Dec 21;89(12):e0145723. doi: 10.1128/aem.01457-23. Epub 2023 Dec 4.
In this study, the mechanism of chromatin regulator Eaf3p regulating nitrogen metabolism in was investigated. It provides theoretical support for epigenetic modifications of cells to alter the level of histone modifications, coordinate the expression of multiple genes, and make it more conducive to the co-metabolism of multiple nitrogen sources. Moreover, it provides new ideas for industrial brewing yeast strains to achieve nitrogen source metabolism balance, reduce the accumulation of harmful nitrogen metabolites, and improve fermentation efficiency. This study provides a reference for changing the performance of microbial strains and improving the quality of traditional fermentation products and provides a theoretical basis for studying epigenetic modification and nitrogen metabolism regulation. It has an important theoretical explanation and practical application value. In addition, this study also provides useful clues for the study.
在这项研究中，研究了染色质调节因子 Eaf3p 调节 中氮代谢的机制。这为细胞的表观遗传修饰提供了理论支持，可改变组蛋白修饰水平，协调多个基因的表达，使其更有利于多种氮源的共代谢。此外，它为工业酿造酵母菌株实现氮源代谢平衡、减少有害氮代谢物的积累和提高发酵效率提供了新的思路。本研究为改变微生物菌株的性能，提高传统发酵产品的质量提供了参考，为研究表观遗传修饰和氮代谢调控提供了理论依据。它具有重要的理论解释和实际应用价值。此外，这项研究还为进一步的研究提供了有用的线索。
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