Li Yang, He Dengqi, Che Yinfu, Zhao Xinchen
Department of Stomatology, Lanzhou University First Affiliated Hospital, Lanzhou University, Lanzhou, China.
Medicine (Baltimore). 2020 Nov 20;99(47):e23302. doi: 10.1097/MD.0000000000023302.
Pulmonary tuberculosis (PTB) is an oldest-known and most formidable disease. The standard microbiology culture is time-wasting. Monokine induced by gamma interferon (MIG) has been reported as a new biomarker to auxiliarily detect PTB. In our study, we used meta-analysis to assess the diagnostic value of MIG for PTB.
PubMed, Embase, Web of Science, and Cochrane Library were searched for relative records up to April 2, 2020. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, area under the curve, and summary receiver operating characteristic curve were estimated.
Eight studies including 1487 participants were included. The pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of MIG for detecting PTB were 84%, 84%, 5.19, and 0.19, respectively. The diagnostic odds ratio and area under the curve were 27.88 and 0.90, respectively, indicating a good diagnostic ability of MIG. Meta-regression analysis showed that human immunodeficiency virus status might be a source of heterogeneity (P = .02).
Our results showed that MIG had a good diagnostic value for PTB.
肺结核（PTB）是一种已知最古老且最具威胁性的疾病。标准微生物培养耗时较长。γ干扰素诱导的单核细胞趋化蛋白（MIG）已被报道为辅助检测PTB的一种新生物标志物。在我们的研究中，我们采用荟萃分析来评估MIG对PTB的诊断价值。
检索了截至2020年4月2日的PubMed、Embase、科学网和Cochrane图书馆的相关记录。估计了合并敏感性、特异性、阳性似然比、阴性似然比、诊断比值比、曲线下面积和汇总接收器操作特征曲线。
纳入了八项研究，共1487名参与者。MIG检测PTB的合并敏感性、特异性、阳性似然比和阴性似然比分别为84%、84%、5.19和0.19。诊断比值比和曲线下面积分别为27.88和0.90，表明MIG具有良好的诊断能力。荟萃回归分析表明，人类免疫缺陷病毒状态可能是异质性的一个来源（P = 0.02）。
我们的结果表明，MIG对PTB具有良好的诊断价值。
