Mitchell Nicole J, Hsu Hui-Husan, Chandyo Ram Krishna, Shrestha Binob, Bodhidatta Ladaporn, Tu Yu-Kang, Gong Yun-Yun, Egner Patricia A, Ulak Manjeswori, Groopman John D, Wu Felicia
Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, United States of America.
Institute of Epidemiology & Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
PLoS One. 2017 Feb 17;12(2):e0172124. doi: 10.1371/journal.pone.0172124. eCollection 2017.
Exposure to aflatoxin, a mycotoxin common in many foods, has been associated with child growth impairment in sub-Saharan Africa. To improve our understanding of growth impairment in relation to aflatoxin and other risk factors, we assessed biospecimens collected in Nepalese children at 15, 24, and 36 months of age for aflatoxin exposure. Children (N = 85) enrolled in the Bhaktapur, Nepal MAL-ED study encompassed the cohort analysed in this study. Exposure was assessed through a plasma biomarker of aflatoxin exposure: the AFB1-lysine adduct. The aflatoxin exposures in the study participants were compared to anthropometrics at each time period (length-for-age [LAZ], weight-for-age [WAZ], and weight-for-length [WLZ] z-scores), growth trajectories over time, age, and breastfeeding status. Results demonstrated chronic aflatoxin exposure in this cohort of children, with a geometric mean of 3.62 pg AFB1-lysine/mg albumin. However, the chronic aflatoxin exposure in this cohort was not significantly associated with anthropometric z-scores, growth trajectories, age, or feeding status, based on the available time points to assess aflatoxin exposure. Low mean levels of aflatoxin exposure and infrequent occurrence of stunting, wasting, or underweight z-score values in this cohort are possible contributing factors to a lack of evidence for an association. Further research is needed to examine whether a threshold dose of aflatoxin exists that could induce child growth impairment.
黄曲霉毒素是许多食物中常见的一种霉菌毒素，在撒哈拉以南非洲地区，接触黄曲霉毒素与儿童生长发育受损有关。为了更好地理解与黄曲霉毒素及其他风险因素相关的生长发育受损情况，我们评估了在尼泊尔儿童15、24和36月龄时收集的生物样本中的黄曲霉毒素暴露情况。参与尼泊尔巴克塔普尔MAL-ED研究的儿童（N = 85）构成了本研究分析的队列。通过黄曲霉毒素暴露的血浆生物标志物：AFB1-赖氨酸加合物来评估暴露情况。将研究参与者的黄曲霉毒素暴露情况与每个时间段的人体测量指标（年龄别身长[LAZ]、年龄别体重[WAZ]和身长别体重[WLZ]z评分）、随时间的生长轨迹、年龄和母乳喂养状况进行比较。结果显示该队列儿童存在慢性黄曲霉毒素暴露，几何平均浓度为3.62 pg AFB1-赖氨酸/毫克白蛋白。然而，基于评估黄曲霉毒素暴露的可用时间点，该队列中的慢性黄曲霉毒素暴露与人体测量z评分、生长轨迹、年龄或喂养状况均无显著关联。该队列中黄曲霉毒素暴露的平均水平较低，且发育迟缓、消瘦或体重不足z评分值出现的频率较低，这可能是缺乏关联证据的促成因素。需要进一步研究来检验是否存在可导致儿童生长发育受损的黄曲霉毒素阈值剂量。
