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基于评分系统的鞍结节脑膜瘤临床特征:印度尼西亚一家机构的经验

Clinical Profile of Tuberculum Sellae Meningiomas Based on Scoring System: An Institutional Experience in Indonesia.

作者信息

Aman Renindra Ananda, Sitorus Risayogi W A H, Rahman Muhamad Aulia, Santoso Fabianto, Kurniawan Ramadhan

机构信息

Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National General Hospital, Jakarta 10430, Indonesia.

出版信息

Cancers (Basel). 2023 Dec 3;15(23):5700. doi: 10.3390/cancers15235700.

Abstract

Tuberculum sellae meningioma (TSM) is a challenging tumor that grows close to several crucial structures, such as the optic nerve, arteries, and pituitary. Surgical treatment is currently evolving from a transcranial microsurgical resection to a transsphenoidal approach. This study examined the clinical profile of patients with tuberculum sellae meningioma and explored its relationship with scoring systems. This retrospective observational study included patients with TSM who underwent surgery at the Department of Neurosurgery at our hospital between 2017 and 2022. The patients were excluded if their data required completion. The clinical profiles of the patients were counted and transformed into a scoring system using several variables such as size, vascular, and canal invasion. We then analyzed the relationship between the clinical signs and symptoms to determine the efficacy of this scoring system. Thirty-six patients were included in the study. Most of our patients had a high score for tumor diameter, bilateral canal invasion, and vascular invasion (2-2-2). Moreover, when related to clinical signs, there was no relationship between the canal and vascular invasion and decreased visual acuity. Tuberculum sellae meningioma mostly causes visual impairment and several other symptoms, such as hemianopsia and parasellar extension. Several factors in the scoring system should also be considered to predict outcomes, such as the onset of visual symptoms, peritumoral edema, and grade of excision.

摘要

鞍结节脑膜瘤(TSM)是一种具有挑战性的肿瘤,其生长靠近视神经、动脉和垂体等多个关键结构。目前,手术治疗正从经颅显微手术切除向经蝶窦入路发展。本研究调查了鞍结节脑膜瘤患者的临床特征,并探讨了其与评分系统的关系。这项回顾性观察性研究纳入了2017年至2022年期间在我院神经外科接受手术的鞍结节脑膜瘤患者。如果患者的数据需要补充,则将其排除。对患者的临床特征进行计数,并使用肿瘤大小、血管和神经通道侵犯等多个变量将其转化为评分系统。然后,我们分析了临床体征和症状之间的关系,以确定该评分系统的有效性。本研究共纳入36例患者。大多数患者在肿瘤直径、双侧神经通道侵犯和血管侵犯方面得分较高(2-2-2)。此外,在临床体征方面,神经通道和血管侵犯与视力下降之间没有关系。鞍结节脑膜瘤主要导致视力损害和其他一些症状,如偏盲和鞍旁扩展。评分系统中的几个因素也应考虑用于预测预后,如视觉症状的发作、瘤周水肿和切除分级。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3632/10705061/d485831db943/cancers-15-05700-g001.jpg

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