Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Chemother. 2024 Apr;36(2):85-109. doi: 10.1080/1120009X.2023.2289270. Epub 2023 Dec 9.
The Human monkeypox virus (mpox) belongs to the Poxviridae family, characterized by double-stranded DNA. A 2022 outbreak, notably prevalent among men who have sex with men, was confirmed by the World Health Organization. To understand shifting prevalence patterns and clinical manifestations, we conducted a systematic review of recent animal and human studies. We comprehensively searched PubMed, Scopus, Web of Science, Cochrane Library, and Clinicaltrials.gov, reviewing 69 relevant articles from 4,342 screened records. Our analysis highlights Modified Vaccinia Ankara - Bavarian Nordic (MVA-BN)'s potential, though efficacy concerns exist. Tecovirimat emerged as a prominent antiviral in the recent outbreak. However, limited evidence underscores the imperative for further clinical trials in understanding and managing monkeypox.
人类猴痘病毒（mpox）属于痘病毒科，其特征是双链 DNA。世界卫生组织证实，2022 年爆发的疫情主要在男男性行为者中流行。为了了解流行趋势和临床表现的变化，我们对最近的动物和人类研究进行了系统综述。我们全面检索了 PubMed、Scopus、Web of Science、Cochrane Library 和 Clinicaltrials.gov，从 4342 篇筛选记录中回顾了 69 篇相关文章。我们的分析强调了改良安卡拉痘苗-巴伐利亚北欧株（MVA-BN）的潜力，尽管存在疗效方面的担忧。特考韦瑞玛特在最近的疫情中成为一种重要的抗病毒药物。然而，有限的证据强调了进一步临床试验的必要性，以了解和管理猴痘。
