Graff M A, Novo R P, Diaz M, Smith C, Hiatt I M, Hegyi T
Pediatr Pulmonol. 1986 Nov-Dec;2(6):332-6. doi: 10.1002/ppul.1950020604.
Dynamic compliance (Cdyn) measurements within the first three days of life predicted survival in 60 preterm infants suffering from respiratory distress syndrome. Cdyn was measured in 47 survivors at 2.3 +/- 1.4 days of life and in 13 nonsurvivors on 2.7 +/- 1.7 days. All nonsurvivors died from respiratory failure within the first two weeks of life. Mean Cdyn of the survivors was 0.83 +/- 0.33 ml/cm H2O and of the nonsurvivors 0.35 +/- 0.19 ml/cm H2O (p less than 0.001). Cdyn values below 0.45 ml/cm H2O predicted 11 of 13 deaths in infants, and Cdyn measurements above this value predicted 45 of 47 survivals, with a specificity of 81% and a sensitivity of 89%. Eleven of the survivors, who subsequently developed bronchopulmonary dysplasia (BPD), had a mean Cdyn of 0.56 +/- 0.23 ml/cm H2O. When these infants were matched with infants of comparable weight without evidence of BPD, the BPD group had a significantly lower Cdyn (p less than 0.05). Cdyn measurements during the first three days of life are useful in predicting outcome of respiratory failure secondary to respiratory distress syndrome.
对60名患有呼吸窘迫综合征的早产儿进行了出生后前三天内的动态顺应性（Cdyn）测量，结果显示其可预测生存情况。47名存活者在出生后2.3±1.4天进行了Cdyn测量，13名非存活者在出生后2.7±1.7天进行了测量。所有非存活者均在出生后两周内死于呼吸衰竭。存活者的平均Cdyn为0.83±0.33ml/cm H2O，非存活者为0.35±0.19ml/cm H2O（p<0.001）。Cdyn值低于0.45ml/cm H2O可预测13名婴儿中的11例死亡，而高于此值的Cdyn测量可预测47例存活者中的45例，特异性为81%，敏感性为89%。11名随后发展为支气管肺发育不良（BPD）的存活者的平均Cdyn为0.56±0.23ml/cm H2O。当将这些婴儿与无BPD证据的体重相当的婴儿进行匹配时，BPD组的Cdyn显著较低（p<0.05）。出生后前三天内的Cdyn测量有助于预测呼吸窘迫综合征继发呼吸衰竭的预后。
