Liu Tianhao, Li Xiaoya, Zhang Chenyang, Zhao Lin, Li Xue, Yu Yusheng, Zhou Yahong, Xue Yuzheng
Affiliated Hospital of Jiangnan University, Wuxi, China.
College of Medicine, Jiangnan University, Wuxi, China.
Heliyon. 2023 Nov 21;9(12):e22572. doi: 10.1016/j.heliyon.2023.e22572. eCollection 2023 Dec.
Previous study confirmed that both TaohongSiwu decoction (THSWD) and improved hypertension-induced endothelial dysfunction. However, the mechanism of THSWD combined with remains unclear.
e: We aimed to investigate the microecological mechanism underlying the THSWD combined with for the prevention of hypertensive vascular endothelial dysfunction.
Eight percent high-salt diet was applied to induce hypertension in a mouse model for 4 weeks. THSWD, and THSWD combined with were used to intervene in the model mice to observe the changes of systolic blood pressure (SBP), body weight, blood routine, endothelial function, gut contents microbiota and bile acid metabolites.
Results revealed that THSWD combined with significantly restored blood pressure and regulated body weight, and markedly downregulating serum and vascular levels of endothelin-1 (ET-1), thrombin regulatory protein (TM), vascular hemophilia factor (vWF) and vascular endothelial growth factor (VEGF), and upregulating nitric oxide (NO) levels compared with the model group. Notably, It altered the diversity and community structure of gut contents microbiota in mice. and was enormously up-regulated at the genus level. Serum bile acid differential metabolites cholic acid and chenodeoxycholic acid were markedly altered. Futhermore, there was a close relationship between and endothelial function indexes in mice.
and play important roles in the prevention of vascular endothelial dysfunction in hypertension during the THSWD combined with .
先前的研究证实，桃红四物汤（THSWD）和[具体药物名称缺失]均可改善高血压诱导的内皮功能障碍。然而，THSWD联合[具体药物名称缺失]的作用机制仍不清楚。
我们旨在探讨THSWD联合[具体药物名称缺失]预防高血压血管内皮功能障碍的微生态机制。
采用8%高盐饮食诱导小鼠高血压模型4周。用THSWD、[具体药物名称缺失]及THSWD联合[具体药物名称缺失]干预模型小鼠，观察收缩压（SBP）、体重、血常规、内皮功能、肠道内容物微生物群及胆汁酸代谢产物的变化。
结果显示，与模型组相比，THSWD联合[具体药物名称缺失]可显著恢复血压、调节体重，显著下调血清和血管中内皮素-1（ET-1）、凝血酶调节蛋白（TM）、血管性血友病因子（vWF）和血管内皮生长因子（VEGF）的水平，并上调一氧化氮（NO）水平。值得注意的是，它改变了小鼠肠道内容物微生物群的多样性和群落结构。在属水平上，[具体菌属名称缺失]和[具体菌属名称缺失]显著上调。血清胆汁酸差异代谢产物胆酸和鹅去氧胆酸明显改变。此外，[具体菌属名称缺失]与小鼠内皮功能指标之间存在密切关系。
[具体药物名称缺失]和[具体菌属名称缺失]在THSWD联合[具体药物名称缺失]预防高血压血管内皮功能障碍中起重要作用。
