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肠道微生物特征比较揭示了 对小鼠的潜在抗衰老功能。

Gut microbial characteristical comparison reveals potential anti-aging function of in mice.

机构信息

Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.

Medical College of Jiangnan University, Wuxi, Jiangsu, China.

出版信息

Front Endocrinol (Lausanne). 2023 Jan 31;14:1133167. doi: 10.3389/fendo.2023.1133167. eCollection 2023.

DOI:10.3389/fendo.2023.1133167
PMID:36798665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9928160/
Abstract

INTRODUCTION

Previous study has indicated may act as a potential probiotic in age-related diseases. However, its detailed role in aging has not yet been promulgated. This study aimed to explore the potential anti-aging role of by comparing the anti-aging effect of resveratrol in young and old mice.

METHOD

Measurement of intestinal aging-related factors in colon and serum, and vascular endothelial function-related factors in serum were performed by enzyme-linked immunosorbent assay (ELISA). Gut microbial analysis of intestinal contents were identified by 16S rRNA gene sequencing.

RESULTS

The effect of on reducing malondialdehyde (MDA) and increasing superoxide dismutase (SOD) in aged mice were greater than that of resveratrol. While the effect of on nitric oxide (NO) level was less than that of resveratrol, the reduction of vascular endothelial growth factor (VEGF) and pentosidine (PTD) was better than that of resveratrol in young mice. In young mice, promoted an increase in the beneficial genus and less effectively as compared with resveratrol treatment. In aged mice, promoted the increase of less effectively than resveratrol, and promoted the increase of expression better as compared with resveratrol treatment. Both young and old mice showed the same results for the remaining markers, including changes in gut microbial composition and predictions of function.

CONCLUSION

has similar anti-aging functions with resveratrol. may even be more effective than resveratrol in reducing oxidative stress, improving vascular endothelial function, and redistributing gut microbiota. The research provides an innovative strategy of to improve aging.

摘要

简介

先前的研究表明，可能在与年龄相关的疾病中发挥潜在的益生菌作用。然而，其在衰老过程中的详细作用尚未公布。本研究旨在通过比较白藜芦醇在年轻和老年小鼠中的抗衰老作用，来探讨的潜在抗衰老作用。

方法

通过酶联免疫吸附测定（ELISA）测定结肠和血清中与肠道衰老相关的因素以及血清中与血管内皮功能相关的因素。通过 16S rRNA 基因测序对肠道内容物中的肠道微生物进行分析。

结果

在降低老年小鼠丙二醛（MDA）和增加超氧化物歧化酶（SOD）方面，的效果大于白藜芦醇。而在降低血管内皮生长因子（VEGF）和戊糖（PTD）方面，的效果优于白藜芦醇，但在提高一氧化氮（NO）水平方面，的效果不如白藜芦醇。在年轻小鼠中，与白藜芦醇处理相比，更有效地促进有益属的增加和减少。在老年小鼠中，与白藜芦醇相比，更有效地促进的增加，但与白藜芦醇相比，的表达增加更好。年轻和老年小鼠的其余标志物（包括肠道微生物组成的变化和功能的预测）都表现出相同的结果。

结论

具有与白藜芦醇相似的抗衰老功能。在降低氧化应激、改善血管内皮功能和重新分配肠道微生物群方面，甚至可能比白藜芦醇更有效。该研究为改善衰老提供了一种创新的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/d37adbb5326b/fendo-14-1133167-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/d614f96c967d/fendo-14-1133167-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/996266ce86dd/fendo-14-1133167-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/877a623073d3/fendo-14-1133167-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/ffed7090fb19/fendo-14-1133167-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/594dcd4e5c58/fendo-14-1133167-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/240a4a3cd3d5/fendo-14-1133167-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/d37adbb5326b/fendo-14-1133167-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/d614f96c967d/fendo-14-1133167-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/c35700103016/fendo-14-1133167-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/996266ce86dd/fendo-14-1133167-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/877a623073d3/fendo-14-1133167-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/ffed7090fb19/fendo-14-1133167-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/594dcd4e5c58/fendo-14-1133167-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/240a4a3cd3d5/fendo-14-1133167-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba58/9928160/d37adbb5326b/fendo-14-1133167-g008.jpg

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