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黄连素的抗氧化和抗关节炎潜力： 及 研究。 （你提供的原文表述似乎不完整，存在信息缺失情况）

Antioxidant and antiarthritic potential of berberine: and studies.

作者信息

Jain Shweta, Tripathi Shalini, Tripathi Pushpendra Kumar

机构信息

Sir Madanlal Institute of Pharmacy, Etawah 206130, India.

Rameshwaram Institute of Technology and Management, Dr. A. P. J. Abdul Kalam Technical University, Lucknow 226001, India.

出版信息

Chin Herb Med. 2023 Sep 12;15(4):549-555. doi: 10.1016/j.chmed.2023.02.007. eCollection 2023 Oct.

DOI:10.1016/j.chmed.2023.02.007
PMID:38094017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10715872/
Abstract

OBJECTIVE

To extract and isolate berberine from (Berberidaceae). Isolated berberine was characterised using spectroscopy and its antioxidant and antiarthritic activity was analyzed.

METHODS

The berberine was isolated from using microwave-assisted extraction (MAE) and characterised by a spectroscopic technique. The isolated berberine was evaluated for its antioxidant activity in DPPH, nitric oxide, and superoxide scavenging assays, while antiarthritic activity was evaluated in the complete freund's adjuvant (CFA)-induced arthritis rat model.

RESULTS

The antioxidant activity of berberine revealed potent antioxidant activity in DPPH, nitric oxide, and superoxide scavenging assays. The antiarthritic activity of berberine in the CFA-induced arthritis rat model showed a significant reduction in paw diameter, arthritic score, and an increase in body weight. Furthermore, a concentration-dependent ameliorating action of berberine on haematological parameters was noticed. Proinflammatory biomarkers, including IL-6, IL-10, and TGF-b in serum were reported, and histopathology examination revealed that berberine decreased pannus formation, synovial hyperplasia, and bone erosion. Radiographic investigation showed soft tissue inflammation, bone resorption and erosion, joint gap reduction, and substantial connective tissue expansion after treatment with berberine.

CONCLUSION

The ameliorating action on haematological parameters and proinflammatory biomarkers of berberine makes them a suitable remedy for the treatment of arthritis.

摘要

目的

从（小檗科）植物中提取和分离黄连素。采用光谱法对分离得到的黄连素进行表征，并分析其抗氧化和抗关节炎活性。

方法

采用微波辅助萃取（MAE）从小檗科植物中分离黄连素，并用光谱技术对其进行表征。在DPPH、一氧化氮和超氧化物清除试验中评估分离得到的黄连素的抗氧化活性，同时在完全弗氏佐剂（CFA）诱导的关节炎大鼠模型中评估其抗关节炎活性。

结果

黄连素的抗氧化活性在DPPH、一氧化氮和超氧化物清除试验中显示出较强的抗氧化活性。黄连素在CFA诱导的关节炎大鼠模型中的抗关节炎活性表现为爪直径显著减小、关节炎评分降低以及体重增加。此外，还观察到黄连素对血液学参数具有浓度依赖性的改善作用。报告了血清中包括IL-6、IL-10和TGF-β在内的促炎生物标志物，组织病理学检查显示黄连素减少了血管翳形成、滑膜增生和骨侵蚀。影像学检查显示，黄连素治疗后出现软组织炎症、骨吸收和侵蚀、关节间隙减小以及大量结缔组织扩张。

结论

黄连素对血液学参数和促炎生物标志物的改善作用使其成为治疗关节炎的合适药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac99/10715872/1e287086dcb0/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac99/10715872/7ef2f8fb864f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac99/10715872/09cf74c5fc6f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac99/10715872/a23338eefb5c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac99/10715872/6336702a2559/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac99/10715872/1e287086dcb0/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac99/10715872/7ef2f8fb864f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac99/10715872/09cf74c5fc6f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac99/10715872/a23338eefb5c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac99/10715872/6336702a2559/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac99/10715872/1e287086dcb0/gr5.jpg

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