用于控制HIV感染和抑制病毒粒子的最佳疗法。

Optimal therapy for HIV infection containment and virions inhibition.

作者信息

Di Giamberardino Paolo, Iacoviello Daniela, Zubair Muhammad

机构信息

Dept. of Computer, Control and Management Engineering, Sapienza, University of Rome, Via Ariosto 25, 00185, Rome, Italy.

出版信息

Infect Dis Model. 2023 Nov 14;9(1):10-26. doi: 10.1016/j.idm.2023.11.006. eCollection 2024 Mar.

DOI:10.1016/j.idm.2023.11.006

PMID:38094224

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10715999/

Abstract

Prevention and early diagnosis are the best and most effective ways for defeating HIV. There is still no vaccine, but treatments with antiretroviral drugs are now available which, in many cases, allow the infection to become chronic. However, research has highlighted side effects of these drugs and the fact that a flare-up of the infection occurs if the therapy is stopped. In recent years, the presence of virus reserves located in various parts of the body, including the brain, has been hypothesized. The possibility of controlling the infection of healthy cells and of interrupting the proliferation of virions inside the brain has been studied, proposing optimal control strategies.

摘要

预防和早期诊断是战胜艾滋病毒的最佳且最有效的方法。目前仍没有疫苗，但现在有抗逆转录病毒药物治疗方法，在许多情况下，这些治疗能使感染转变为慢性感染。然而，研究突出了这些药物的副作用以及如果停止治疗感染就会复发这一事实。近年来，人们推测在包括大脑在内的身体各个部位存在病毒储存库。已经研究了控制健康细胞感染以及阻断大脑内病毒粒子增殖的可能性，并提出了最佳控制策略。