Department of Pediatric Neurology, Tepecik Training and Research Hospital, Izmir Katip Celebi University, Izmir, Turkey.
Department of Pediatrics, Tepecik Training and Research Hospital, University of Health Sciences, Izmir, Turkey.
Breastfeed Med. 2023 Dec;18(12):908-912. doi: 10.1089/bfm.2023.0125.
Immaturity of the digestive tract and enteric nervous system is a widely accepted theory for infantile colic (IC) etiopathogenesis. The study aimed to show whether neurotrophins that are necessary for normal functioning and development of the gastrointestinal system have a role in the pathogenesis of IC. The IC group ( = 75) comprising the mothers of infants with IC and the control group ( = 75) were included to this cross-sectional case-control study. Brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF), ciliary neurotrophic factor (CNTF), and nerve growth factor (NGF) levels of breast milk samples were evaluated by immunosorbent analysis method. The mean age of infants with IC was 7.3 ± 2.8 weeks, while the mean age of the control group was 8.1 ± 2.9 weeks ( = 0.110). No significant difference was found between the breast milk BDNF, GDNF, CNTF, and NGF levels of two groups ( = 0.941, = 0.510, = 0.533, = 0.839, respectively). This is the first report comparing the neurotrophin levels of the breast milk samples taken from the mothers of infants with and without IC. The study demonstrated that breast milk neurotrophin levels of the mothers did not differ significantly between the infants with and without IC.
肠道和肠神经系统不成熟是婴儿绞痛（IC）发病机制的一个广泛接受的理论。本研究旨在表明，对于胃肠道系统的正常功能和发育所必需的神经营养因子是否在 IC 的发病机制中起作用。本横断面病例对照研究纳入了 75 名患有 IC 的婴儿的母亲组成的 IC 组和 75 名对照组。通过免疫吸附分析法评估母乳样本中的脑源性神经营养因子（BDNF）、胶质细胞源性神经营养因子（GDNF）、睫状神经营养因子（CNTF）和神经生长因子（NGF）水平。IC 组婴儿的平均年龄为 7.3±2.8 周，而对照组的平均年龄为 8.1±2.9 周（=0.110）。两组母乳 BDNF、GDNF、CNTF 和 NGF 水平无显著差异（=0.941、=0.510、=0.533、=0.839，分别）。这是首次比较患有和不患有 IC 的婴儿的母亲母乳样本中神经营养因子水平的报告。该研究表明，患有和不患有 IC 的婴儿的母亲母乳神经营养因子水平无显著差异。
