From the Department of Anesthesiology, Critical Care and Pain Medicine, Hospital for Special Surgery, New York, New York.
Department of Anesthesiology, Weill Cornell Medicine, New York, New York.
Anesth Analg. 2024 Jan 1;138(1):42-53. doi: 10.1213/ANE.0000000000006472. Epub 2023 Dec 15.
The cannabis plant has been used for centuries to manage the symptoms of various ailments including pain. Hundreds of chemical compounds have been identified and isolated from the plant and elicit a variety of physiological responses by binding to specific receptors and interacting with numerous other proteins. In addition, the body makes its own cannabinoid-like compounds that are integrally involved in modulating normal and pathophysiological processes. As the legal cannabis landscape continues to evolve within the United States and throughout the world, it is important to understand the rich science behind the effects of the plant and the implications for providers and patients. This narrative review aims to provide an overview of the basic science of the cannabinoids by describing the discovery and function of the endocannabinoid system, pharmacology of cannabinoids, and areas for future research and therapeutic development as they relate to perioperative and chronic pain medicine.
大麻植物已经被使用了几个世纪，用于治疗各种疾病的症状，包括疼痛。已经从该植物中鉴定和分离出数百种化学化合物，这些化合物通过与特定受体结合并与许多其他蛋白质相互作用，引起各种生理反应。此外，人体自身产生类似大麻的化合物，这些化合物对于调节正常和病理生理过程至关重要。随着美国和世界各地的合法大麻环境不断发展，了解该植物作用背后的丰富科学知识以及对提供者和患者的影响非常重要。本叙事综述旨在通过描述内源性大麻素系统的发现和功能、大麻素的药理学以及与围手术期和慢性疼痛医学相关的未来研究和治疗开发领域，概述大麻素的基础科学。
