School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning Province, People's Republic of China.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning Province, People's Republic of China.
Talanta. 2024 Apr 1;270:125487. doi: 10.1016/j.talanta.2023.125487. Epub 2023 Nov 28.
Antioxidants and UV stabilizers have some endocrine disrupting effects and liver toxicity. Both types of additives are still widely used in food contact plastics to improve the durability of plastic products. However, efficient and rapid detection of antioxidants and UV stabilizers has been a challenge due to the complexity of the plastic matrix and the low content of antioxidants and UV stabilizers. In this study, a sodium alginate/MOF-derived magnetic multistage pore carbon material (MIL-101(Fe)/SA-CAs) was developed, having the merits of abundant multistage pore structure, large specific surface area, and good magnetic separation properties. Thus, this material was selected as the sorbent for magnetic solid-phase extraction combined with a dissolution-precipitation method for the extraction and purification of antioxidants and UV stabilizers from polylactic acid food contact plastics. The extraction parameters such as sorbent type, sorbent dosage, sample solution pH, ionic strength, sorption time, elution solution type, volume, and time were investigated. Under the optimized conditions, all the analytes determined by UPLC-MS/MS showed good linear range (r > 0.99), detection limit (0.023-3.105 ng g), accuracy (70.6-102.3 %), and reproducibility (RSD<9.8 %). Further, the developed method was applied to determine the antioxidants and UV stabilizers in polylactic acid lunch boxes and straws, showing excellent applicability. The results showed that the antioxidants and UV stabilizers were detected in some of the samples, with a maximum detection of antioxidant 1010 at 7297 ng g. This study provided a sensitive, efficient, and environmentally friendly method for antioxidants and UV stabilizers in polylactic acid food contact plastics. The ideas for the design of environmentally friendly metal-organic frameworks and biomass composite multifunctional materials would promise in the sample pretreatment field for the emerging contaminants.
抗氧化剂和紫外线稳定剂具有一些内分泌干扰作用和肝毒性。这两种类型的添加剂仍广泛用于食品接触塑料中，以提高塑料产品的耐用性。然而，由于塑料基质的复杂性和抗氧化剂和紫外线稳定剂含量低，高效快速地检测抗氧化剂和紫外线稳定剂一直是一个挑战。在这项研究中，开发了一种海藻酸钠/金属有机骨架衍生的磁性多级孔碳材料（MIL-101(Fe)/SA-CAs），具有丰富的多级孔结构、大比表面积和良好的磁分离性能。因此，该材料被选为用于磁性固相萃取的吸附剂，结合溶解沉淀法从聚乳酸食品接触塑料中提取和纯化抗氧化剂和紫外线稳定剂。研究了吸附剂类型、吸附剂用量、样品溶液 pH 值、离子强度、吸附时间、洗脱溶液类型、体积和时间等提取参数。在优化条件下，所有通过 UPLC-MS/MS 测定的分析物均表现出良好的线性范围（r＞0.99）、检测限（0.023-3.105ng g）、准确度（70.6-102.3%）和重现性（RSD＜9.8%）。此外，该方法还应用于测定聚乳酸餐盒和吸管中的抗氧化剂和紫外线稳定剂，具有良好的适用性。结果表明，在一些样品中检测到了抗氧化剂和紫外线稳定剂，最大检测到的抗氧化剂 1010 为 7297ng g。本研究为聚乳酸食品接触塑料中抗氧化剂和紫外线稳定剂的检测提供了一种灵敏、高效、环保的方法。为新兴污染物的样品预处理领域提供了设计环保型金属有机骨架和生物质复合材料多功能材料的思路。
