Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt.
Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; Department of Biochemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr city, Cairo 11823, Egypt.
Pathol Res Pract. 2024 Jan;253:155027. doi: 10.1016/j.prp.2023.155027. Epub 2023 Dec 11.
Oral cancer (OC) is a widely observed neoplasm on a global scale. Over time, there has been an increase in both its fatality and incidence rates. Oral cancer metastasis is a complex process that involves a number of cellular mechanisms, including invasion, migration, proliferation, and escaping from malignant tissue through either lymphatic or vascular channels. MicroRNAs (miRNAs) are a crucial class of short non-coding RNAs recognized as significant modulators of diverse cellular processes and exert a pivotal influence on the carcinogenesis pathway, functioning either as tumor suppressors or as oncogenes. It has been shown that microRNAs (miRNAs) have a role in metastasis at several stages, including epithelial-mesenchymal transition, migration, invasion, and colonization. This regulation is achieved by targeting key genes involved in these pathways by miRNAs. This paper aims to give a contemporary analysis of OC, focusing on its molecular genetics. The current literature and emerging advancements in miRNA dysregulation in OC are thoroughly examined. This project would advance OC diagnosis, prognosis, therapy, and therapeutic implications.
口腔癌（OC）是一种在全球范围内广泛观察到的肿瘤。随着时间的推移，其死亡率和发病率都有所上升。口腔癌转移是一个复杂的过程，涉及许多细胞机制，包括侵袭、迁移、增殖以及通过淋巴或血管通道从恶性组织中逃逸。微小 RNA（miRNA）是一类重要的短非编码 RNA，被认为是多种细胞过程的重要调节剂，对致癌途径有重要影响，可作为肿瘤抑制因子或癌基因发挥作用。已经表明，miRNA 在转移的几个阶段发挥作用，包括上皮-间充质转化、迁移、侵袭和定植。miRNA 通过靶向这些途径中的关键基因来实现这种调节。本文旨在对 OC 进行现代分析，重点关注其分子遗传学。深入研究了 OC 中 miRNA 失调的当前文献和新进展。该项目将推进 OC 的诊断、预后、治疗和治疗意义。
