Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Vets4Pets Newmarket, Inside Pets at Home, Studland Retail Park, Newmarket, Suffolk, UK.
J Comp Pathol. 2024 Jan;208:33-36. doi: 10.1016/j.jcpa.2023.11.004. Epub 2023 Dec 14.
An adult sulphur-crested cockatoo (Cacatua galerita) was unexpectedly found dead and was presented for post-mortem examination. Macroscopically, the proventricular wall was expanded by an infiltrative off-white mass, 10 mm in diameter, with secondary mucosal ulceration. Cytological examination of impression smears revealed a neoplastic epithelial cell population forming occasional well-defined acini with secretory product. Histologically, the neoplastic cells were predominantly arranged in acini and tubules, with fewer in small clusters, supported by a desmoplastic stroma. Neoplastic cells were polygonal, with mostly well-demarcated cell boundaries and a moderate amount of eosinophilic cytoplasm that was multifocally markedly distended by more intensely eosinophilic material. There was an increased nuclear-to-cytoplasmic ratio with moderately sized to large nuclei (approximately 15 μm diameter) with lightly to densely stippled chromatin and single or paired prominent basophilic nucleoli. The mitotic count was 19 in 10 high-power fields (2.37 mm), with scattered bizarre mitotic figures and atypia including moderate anisocytosis and anisokaryosis and moderate cellular and nuclear pleomorphism. There was frequent intratubular brightly eosinophilic proteinaceous material, which was Alcian blue and periodic acid‒Schiff positive. Proventricular lymphovascular invasion was detected, with metastases within the ventriculus and lungs. The macroscopic, cytological and histological appearance of the neoplasm was consistent with a proventricular adenocarcinoma.
一只成年硫冠凤头鹦鹉（Cacatua galerita）意外死亡，被送检进行剖检。大体检查发现，前胃壁被一个直径 10 毫米的浸润性灰白色肿块扩张，伴有继发性黏膜溃疡。触片细胞学检查显示，有一群肿瘤上皮细胞偶尔形成界限清楚的腺泡，有分泌产物。组织学上，肿瘤细胞主要排列成腺泡和小管，少数呈小簇状，由纤维母细胞性基质支撑。肿瘤细胞为多边形，细胞边界大多清楚，胞质呈中等量嗜酸性，局部呈多灶性显著扩张，呈嗜酸性更强的物质。细胞核与细胞质的比例增加，细胞核大小中等至较大（直径约 15μm），染色质轻度至重度颗粒状，有一个或两个明显的嗜碱性核仁。10 个高倍视野中有 19 个有丝分裂（2.37mm），有散在的奇异有丝分裂象和非典型性，包括中度的大小不均和核型不均，以及中度的细胞和核多形性。管腔内常有明亮的嗜酸性蛋白物质，对阿尔辛蓝和过碘酸希夫染色呈阳性。前胃的血管淋巴管浸润，心室和肺部有转移。肿瘤的大体、细胞学和组织学表现与前胃腺癌一致。
