Department of Applied Behavioral Science, University of Kansas, USA.
Department of Behavioral and Social Sciences, Brown University, USA; Center for Alcohol and Addiction Studies, Brown University, USA.
Drug Alcohol Depend. 2024 Jan 1;254:111057. doi: 10.1016/j.drugalcdep.2023.111057. Epub 2023 Dec 9.
Given the expanding legal cannabis market in the U.S., it is vital to understand how context impacts cannabis use. Therefore, we explored the effect of cannabis cues and cannabis-use context on cannabis demand in 79 adults who reported smoking cannabis at least weekly.
Participants completed a single laboratory session consisting of four hypothetical marijuana purchase tasks (MPTs) involving either a typical use situation or a driving or sleep context. The MPTs were alternated with exposure to cannabis or neutral picture cues based on block randomization by gender.
Cannabis cues increased self-reported craving for cannabis (p =.044) but did not significantly alter demand (ps =0.093-0.845). In the driving context, participants demonstrated a significant reduction in cannabis demand, indicated by lower intensity (p <0.001), O (p <0.001), and P (p <0.001), breakpoint (p =.003), and higher α (p <0.001). The sleep context was associated with significantly greater α (p <0.006) but nonsignificant effects for other indices (ps =0.123-0.707). Finally, cannabis cues increased O (p =.013) and breakpoint (p =.035) in the sleep context but not in the typical-use context.
These findings suggest that cannabis-use behavior is sensitive to contingencies surrounding driving after cannabis use and may also be sensitive to sleep contexts in the presence of cannabis cues. Since this is the first study to examine driving and sleep contexts, we caution against drawing broad conclusions until future research is conducted to replicate these findings.
鉴于美国不断扩大的合法大麻市场，了解情境如何影响大麻使用至关重要。因此，我们探讨了大麻线索和大麻使用情境对 79 名至少每周吸食大麻的成年人的大麻需求的影响。
参与者完成了一个包含四个假设大麻购买任务（MPT）的单一实验室会议，这些任务涉及典型使用情境或驾驶或睡眠情境。根据性别进行块随机化，MPT 与大麻或中性图片线索的暴露交替进行。
大麻线索增加了自我报告的大麻渴望（p=.044），但并未显著改变需求（p 值=0.093-0.845）。在驾驶情境中，参与者表现出大麻需求的显著降低，表现为较低的强度（p<.001）、O（p<.001）和 P（p<.001）、断点（p=.003）和较高的α（p<.001）。睡眠情境与显著更大的α（p<.006）相关，但其他指标的影响不显著（p 值=0.123-0.707）。最后，大麻线索在睡眠情境中增加了 O（p=.013）和断点（p=.035），但在典型使用情境中没有增加。
这些发现表明，大麻使用行为对使用大麻后的驾驶环境中的条件刺激敏感，并且在存在大麻线索的情况下也可能对睡眠环境敏感。由于这是第一个研究驾驶和睡眠环境的研究，我们在未来开展研究复制这些发现之前，应谨慎得出广泛的结论。
