Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts, USA; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts, USA; Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Sleep Health. 2024 Feb;10(1S):S157-S160. doi: 10.1016/j.sleh.2023.11.002. Epub 2023 Dec 15.
Comorbid insomnia and sleep apnea is reported to have worse outcomes than either condition alone. The local genetic correlations of these disorders are unknown.
To identify local genomic regions with heritability for clinically diagnosed sleep apnea and insomnia, and to identify local genetic correlations between these disorders and/or hypersomnia.
Fifty thousand two hundred seventeen patients of European ancestry were examined. Global and local heritability and genetic correlations for independent regions were calculated, adjusting for obesity and other covariates.
Sleep apnea and insomnia were significantly globally heritable and had 118 and 168 genetic regions with local heritability p-values <.05, respectively. One region had a significant genetic correlation for sleep apnea and hypersomnia (p-value = 9.85 × 10).
Clinically diagnosed sleep apnea and insomnia have minimal shared genetic architecture, supporting genetically distinct comorbid insomnia and sleep apnea components. However, additional correlated regions may be identified with additional sample size and methodological improvements.
合并失眠和睡眠呼吸暂停的病症据报道比任一单一病症的后果更差。这些病症的局部遗传相关性尚不清楚。
确定临床上诊断的睡眠呼吸暂停和失眠的遗传性局部基因组区域,并确定这些病症与嗜睡症之间的局部遗传相关性。
对 5217 名欧洲血统的患者进行了检查。调整肥胖和其他协变量后,计算了独立区域的全球和局部遗传率以及遗传相关性。
睡眠呼吸暂停和失眠在全球范围内具有显著的遗传性,分别有 118 个和 168 个具有局部遗传率 p 值 <.05 的遗传区域。一个区域的睡眠呼吸暂停和嗜睡症之间存在显著的遗传相关性(p 值 = 9.85×10)。
临床上诊断的睡眠呼吸暂停和失眠具有最小的共同遗传结构,支持嗜睡症和睡眠呼吸暂停成分在遗传上是不同的。然而,随着样本量的增加和方法学的改进,可能会发现更多相关的区域。