Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Cell Infect Microbiol. 2023 Dec 1;13:1298050. doi: 10.3389/fcimb.2023.1298050. eCollection 2023.
The study aimed to comprehensively describe and evaluate the pathogenic and clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) patients with co-infections.
We retrospectively collected clinical data and laboratory indicators of the SFTS patients at Tongji Hospital from October 2021 to July 2023.
A total of 157 patients with SFTS virus (SFTSV) infection were involved in the analysis, including 43 co-infection and 114 non-co-infection patients. The pathogens responsible for co-infection were primarily isolated from respiratory specimens. Fungal infections, primarily , were observed in 22 cases. Bacterial infections, with and carbapenem-resistant as the main pathogens, were identified in 20 cases. SFTS patients with co-infection exhibited higher mortality (=0.011) compared to non-co-infection patients. Among SFTS patients co-infected with both bacteria and fungi (8 cases) or specific drug-resistant strains (11 cases), the mortality rate was as high as 70% (14/19). In comparison with the non-co-infection group, SFTS patients with co-infection displayed significant alteration in inflammatory markers, coagulation function, and liver function indicators.
The mortality rate of SFTS patients with co-infection is relatively high, underscoring the need for enhanced monitoring and timely, appropriate treatment to minimize the mortality rate.
本研究旨在全面描述和评估伴有合并感染的严重发热伴血小板减少综合征（SFTS）患者的病原体和临床特征。
我们回顾性收集了 2021 年 10 月至 2023 年 7 月期间在同济医院就诊的 SFTS 患者的临床数据和实验室指标。
共纳入了 157 例 SFTS 病毒（SFTSV）感染患者，其中 43 例为合并感染患者，114 例为非合并感染患者。合并感染的病原体主要从呼吸道标本中分离得到。22 例患者合并真菌感染，主要为。20 例患者合并细菌感染，以 和 碳青霉烯类耐药 为主要病原体。合并感染患者的死亡率（=0.011）高于非合并感染患者。在同时合并细菌和真菌感染（8 例）或特定耐药菌株感染（11 例）的 SFTS 患者中，死亡率高达 70%（14/19）。与非合并感染组相比，合并感染的 SFTS 患者的炎症标志物、凝血功能和肝功能指标均有显著改变。
合并感染的 SFTS 患者的死亡率相对较高，需要加强监测，并及时、恰当地治疗，以降低死亡率。
