Beljanski M, Plawecki M
Exp Cell Biol. 1979;47(3):218-25. doi: 10.1159/000162939.
Under well-defined conditions, ribosomal RNA from Escherichia coli is fragmented by pancreatic ribonuclease, leading to the appearance of particular RNA fragments. Some of these fragments act as primers for in vitro replication of DNA extracted from blood-cell and platelet-forming tissues. In experimental rabbits they restore in a rapid and harmless way normal circulating leukocyte and platelet levels when these have been drastically decreased by various chemotherapeutic agents mainly used in anticancer therapy. Imbalance between polynuclear and lymphocyte count provoked in rabbits by cyclophosphamide can be rapidly corrected by treating the animal with active RNA fragments.
在明确界定的条件下，大肠杆菌的核糖体核糖核酸（rRNA）会被胰核糖核酸酶裂解，从而产生特定的RNA片段。其中一些片段可作为引物，用于体外复制从血细胞和血小板生成组织中提取的DNA。在实验兔中，当主要用于抗癌治疗的各种化疗药物大幅降低正常循环白细胞和血小板水平时，这些片段能以快速且无害的方式使其恢复。用环磷酰胺诱发的兔多核细胞与淋巴细胞计数失衡，可通过用活性RNA片段治疗动物而迅速得到纠正。
