Watson R G, McMillan S A, Dolan C, O'Farrelly C, Cuthbert R J, Haire M, Weir D G, Porter K G
Ulster Med J. 1986 Oct;55(2):160-4.
Circulating antigliadin antibody has been described in patients with gluten enteropathy although the prevalence varies in different studies. It has been suggested that the investigation for antigliadin antibody might be useful as a screening test. The object of the present study was to evaluate two different techniques for assaying these antibodies - an indirect immunofluorescent method and an enzyme-linked immunosorbent assay (ELISA). Antibodies were assayed in the sera of 102 patients in whom jejunal biopsies were also obtained. The specificity of both tests was greater than 95%, and the correlation between the presence of antibody and histology was significant (p < 0.005), though the sensitivity of each test was less than 70%.
尽管不同研究中麸质肠病患者循环抗麦醇溶蛋白抗体的患病率有所不同，但已有相关描述。有人提出，抗麦醇溶蛋白抗体检测作为一种筛查试验可能有用。本研究的目的是评估两种不同的检测这些抗体的技术——间接免疫荧光法和酶联免疫吸附测定（ELISA）。在102例同时进行了空肠活检的患者血清中检测了抗体。两种检测方法的特异性均大于95%，抗体存在与组织学之间的相关性显著（p < 0.005），不过每种检测方法的敏感性均低于70%。
