Leeds Institute of Health Sciences, University of Leeds Faculty of Medicine and Health, Leeds, UK
Leeds Institute of Health Sciences, University of Leeds Faculty of Medicine and Health, Leeds, UK.
BMJ Open. 2023 Dec 18;13(12):e078703. doi: 10.1136/bmjopen-2023-078703.
Aspirin could be offered for colorectal cancer prevention for the UK general population. To ensure the views of the general population are considered in future guidance, we explored public perceptions of aspirin for preventive therapy.
We conducted an online survey to investigate aspirin use, and awareness of aspirin for cancer prevention among the UK general population. We conducted semistructured interviews with a subsample of survey respondents to explore participants' acceptability towards aspirin for cancer preventive therapy. We analysed the interview data using reflexive thematic analysis and mapped the themes onto the Theoretical Domains Framework, and the Necessity and Concerns Framework.
Online survey and remote interviews.
We recruited 400 UK respondents aged 50-70 years through a market research company to the survey. We purposefully sampled, recruited and interviewed 20 survey respondents.
In the survey, 19.0% (76/400) of respondents were aware that aspirin can be used to prevent cancer. Among those who had previously taken aspirin, 1.9% (4/216) had taken it for cancer prevention. The interviews generated three themes: (1) perceived necessity of aspirin; (2) concerns about side effects; and (3) preferred information sources. Participants with a personal or family history of cancer were more likely to perceive aspirin as necessary for cancer prevention. Concerns about taking aspirin at higher doses and its side effects, such as gastrointestinal bleeding, were common. Many described wanting guidance and advice on aspirin to be communicated from sources perceived as trustworthy, such as healthcare professionals.
Among the general population, those with a personal or family history of cancer may be more receptive towards taking aspirin for preventive therapy. Future policies and campaigns recommending aspirin may be of particular interest to these groups. Multiple considerations about the benefits and risks of aspirin highlight the need to support informed decisions on the medication.
阿司匹林可用于英国普通人群的结直肠癌预防。为确保在未来的指南中考虑到普通人群的观点，我们探讨了公众对阿司匹林用于预防治疗的看法。
我们进行了一项在线调查，以调查英国普通人群中阿司匹林的使用情况以及对阿司匹林预防癌症的认识。我们对调查的一部分受访者进行了半结构式访谈，以探讨参与者对阿司匹林用于癌症预防治疗的接受程度。我们使用反思性主题分析对访谈数据进行分析，并将主题映射到理论领域框架和必要性和关注框架上。
在线调查和远程访谈。
我们通过市场研究公司招募了 400 名年龄在 50-70 岁之间的英国受访者参与调查。我们有目的地对 20 名调查受访者进行了抽样、招募和访谈。
在调查中，19.0%（400 名中的 76 名）的受访者知道阿司匹林可用于预防癌症。在以前服用过阿司匹林的人中，1.9%（216 名中的 4 名）曾因预防癌症而服用。访谈产生了三个主题：（1）对阿司匹林的必要性的认识；（2）对副作用的担忧；（3）首选信息来源。有癌症个人或家族史的参与者更有可能认为阿司匹林对预防癌症是必要的。对服用高剂量阿司匹林及其副作用（如胃肠道出血）的担忧很常见。许多人表示希望从被认为可信的来源（如医疗保健专业人员）获得关于阿司匹林的指导和建议。
在普通人群中，有癌症个人或家族史的人可能更容易接受阿司匹林的预防治疗。未来推荐阿司匹林的政策和运动可能对这些群体特别感兴趣。对阿司匹林的益处和风险的多种考虑突显了支持对药物做出明智决策的必要性。
