Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, New York, USA.
mBio. 2024 Jan 16;15(1):e0225023. doi: 10.1128/mbio.02250-23. Epub 2023 Dec 19.
As demonstrated by severe acute respiratory syndrome coronavirus 2, coronaviruses pose a significant pandemic threat. Here, we show that coronavirus disease 2019 mRNA vaccination can induce significant levels of cross-reactive antibodies against diverse coronavirus spike proteins. While these antibodies are binding antibodies that likely have little neutralization capacity and while their contribution to cross-protection is unclear, it is possible that they may play a role in protection from progression to severe disease with novel coronaviruses.
正如严重急性呼吸综合征冠状病毒 2 所表明的那样，冠状病毒构成了重大的大流行威胁。在这里，我们表明，2019 年冠状病毒病 mRNA 疫苗接种可以诱导针对多种冠状病毒刺突蛋白的显著水平的交叉反应性抗体。虽然这些抗体是结合抗体，可能几乎没有中和能力，而它们对交叉保护的贡献尚不清楚，但它们可能在预防新型冠状病毒进展为严重疾病方面发挥作用。
