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T4和TD3改善高脂饮食喂养的C57BL/6J小鼠骨骼肌的氧化应激和炎症。

T4 and TD3 Ameliorate Skeletal Muscle Oxidative Stress and Inflammation in High-Fat Diet-Fed C57BL/6J Mice.

作者信息

Shams Masoumeh, Esmaeili Fataneh, Sadeghi Samira, Shanaki-Bavarsad Mahsa, Seyyed Ebrahimi Shadi Sadat, Hashemnia Seyyed Mohammad Reza, Tajabadi-Ebrahimi Maryam, Emamgholipour Solaleh, Shanaki Mehrnoosh

机构信息

Department of Medical Laboratory Sciences, School of Allied Medical Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences Tehran, Iran.

出版信息

Iran J Pharm Res. 2023 Jul 23;22(1):e135249. doi: 10.5812/ijpr-135249. eCollection 2023 Jan-Dec.

DOI:10.5812/ijpr-135249
PMID:38116571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10728858/
Abstract

BACKGROUND

This study aims to investigate the effects of T4 and TD3 probiotics on skeletal muscle inflammation and oxidative stress in C57BL/6J mice fed a high-fat diet (HFD).

METHODS

Probiotics T4, and TD3 were administered to male C57BL/6J mice fed with HFD. The gene expression of macrophage infiltration markers, inflammatory cytokines, and oxidative stress indicators in the muscle tissue was investigated.

RESULTS

Treatment with T4 and TD3 reduced macrophage infiltration, accompanied by a decrease in the expression of monocyte chemoattractant protein-1 (MCP-1) and an increase in the expression of interleukin (IL)-10. On the other hand, TD3 decreased malondialdehyde (MDA) while T4 decreased carbonyl and increased catalase activity.

CONCLUSIONS

Treatment with probiotics T4 and TD3 partially ameliorated obesity-induced skeletal muscle inflammation in HFD-fed mice.

摘要

背景

本研究旨在调查T4和TD3益生菌对高脂饮食（HFD）喂养的C57BL/6J小鼠骨骼肌炎症和氧化应激的影响。

方法

将益生菌T4和TD3给予高脂饮食喂养的雄性C57BL/6J小鼠。研究肌肉组织中巨噬细胞浸润标志物、炎性细胞因子和氧化应激指标的基因表达。

结果

用T4和TD3处理可减少巨噬细胞浸润，同时单核细胞趋化蛋白-1（MCP-1）表达降低，白细胞介素（IL）-10表达增加。另一方面，TD3可降低丙二醛（MDA），而T4可降低羰基并增加过氧化氢酶活性。

结论

用益生菌T4和TD3处理可部分改善高脂饮食喂养小鼠中肥胖诱导的骨骼肌炎症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a0/10728858/a9957cd59395/ijpr-22-1-135249-i004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a0/10728858/fb6054702b96/ijpr-22-1-135249-i001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a0/10728858/2dd543f811ec/ijpr-22-1-135249-i002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a0/10728858/9c02c857cc0e/ijpr-22-1-135249-i003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a0/10728858/a9957cd59395/ijpr-22-1-135249-i004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a0/10728858/fb6054702b96/ijpr-22-1-135249-i001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a0/10728858/2dd543f811ec/ijpr-22-1-135249-i002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a0/10728858/9c02c857cc0e/ijpr-22-1-135249-i003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a0/10728858/a9957cd59395/ijpr-22-1-135249-i004.jpg

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