Lydrup M L, Hellstrand P
Acta Physiol Scand. 1986 Dec;128(4):525-33. doi: 10.1111/j.1748-1716.1986.tb08008.x.
The rates of oxygen consumption and lactate production in the guinea-pig oviduct were measured together with registration of contractile activity during three phases of the hormonal cycle. In pro-oestrus (high oestrogen, low progesterone levels) and oestrus (time of ovulation, high oestrogen and progesterone) the rate of O2 consumption was higher than in dioestrus (low oestrogen, high progesterone). The frequency of spontaneous contractions was higher in oestrus than in the other phases. No significant differences in the proportion of the cross-sectional area occupied by smooth muscle were found between oviducts in di- and pro-oestrus. Stimulation by phenylephrine caused decreased frequency and increased amplitude of contractions in dioestrus but not in pro-oestrus, suggesting hormonal modulation of adrenergic mechanisms. The rate of relaxation of high-K+ contractures was higher in pro- than dioestrus. Lactate production and contents of ATP, ADP and phosphocreatine showed no significant variation with hormonal state. The increased rate of oxidative metabolism under oestrogenic dominance could in part reflect changes in ionic transport mechanisms, such as intracellular Ca2+ handling.
在激素周期的三个阶段，对豚鼠输卵管的耗氧率和乳酸生成率进行了测量，并记录了收缩活动。在发情前期（雌激素水平高、孕酮水平低）和发情期（排卵时间，雌激素和孕酮水平高），耗氧率高于间情期（雌激素水平低、孕酮水平高）。发情期自发收缩的频率高于其他阶段。在间情期和发情前期的输卵管中，平滑肌所占横截面积的比例没有显著差异。苯肾上腺素刺激使间情期收缩频率降低、幅度增加，但发情前期没有，这表明激素对肾上腺素能机制有调节作用。高钾挛缩的舒张速率在发情前期高于间情期。乳酸生成以及ATP、ADP和磷酸肌酸的含量随激素状态没有显著变化。雌激素占优势时氧化代谢率的增加可能部分反映了离子转运机制的变化，如细胞内钙离子的处理。
