Maj M
Acta Psychiatr Scand. 1986 Nov;74(5):524-8. doi: 10.1111/j.1600-0447.1986.tb06278.x.
Neuropsychological functioning in schizoaffective disorder, depressed type, was tested by two parallel studies. In Study 1, the Luria-Nebraska Neuropsychological Battery (LNNB) was administered to samples of patients meeting Research Diagnostic Criteria (RDC) for schizodepressive disorder, major depressive disorder or schizophrenia, and to a normal control group. In Study 2, the same test battery was used in patients with a former RDC diagnosis of schizodepressive or major depressive disorder, examined from 2 to 4 years after the index episode, during a phase of remission. Study 1 showed that the performance of schizodepressives on LNNB is, on average, intermediate between those of depressives and schizophrenics, which finding is compatible with the view that RDC schizoaffective depression encompasses a heterogeneous group of syndromes, some of which are related to major depression and some to schizophrenia. Study 2 showed that the mean scores on the LNNB scales Memory and Intellectual processes are significantly higher in patients with a former diagnosis of schizodepressive disorder, which supports the idea that the outcome of these patients is worse, on average, than that of "pure" depressives.
通过两项平行研究对分裂情感性障碍抑郁型的神经心理功能进行了测试。在研究1中，对符合精神分裂症抑郁症、重度抑郁症或精神分裂症研究诊断标准（RDC）的患者样本以及正常对照组施行了鲁利亚-内布拉斯加神经心理成套测验（LNNB）。在研究2中，对曾被RDC诊断为精神分裂症抑郁症或重度抑郁症的患者使用了相同的测试组合，这些患者在首次发作后的2至4年、缓解期接受检查。研究1表明，精神分裂症抑郁症患者在LNNB上的表现平均介于抑郁症患者和精神分裂症患者之间，这一发现与以下观点相符：RDC分裂情感性抑郁症包含一组异质性综合征，其中一些与重度抑郁症有关，一些与精神分裂症有关。研究2表明，曾被诊断为精神分裂症抑郁症的患者在LNNB量表“记忆”和“智力过程”上的平均得分显著更高，这支持了以下观点：平均而言，这些患者的预后比“单纯”抑郁症患者更差。
