School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia.
Sport Science Academy, Wollo University, Dessie, Ethiopia.
Sci Rep. 2023 Dec 20;13(1):22772. doi: 10.1038/s41598-023-49039-8.
The relationship between normal-weight obesity (NWO)-high percent body fat (%BF) in individuals with normal body mass index (BMI)-and cardiometabolic abnormalities has not been explored in Africa. We determined the prevalence of the NWO and evaluated its association with hypertension, elevated blood sugar and dyslipidaemia among adults in Addis Ababa, Ethiopia. A cross-sectional study was conducted among adults 18-64 years (n = 600). Blood pressure, blood glucose, lipid profile, and anthropometric measurements were completed. As a function of skinfold thickness, body density and %BF were estimated using Durnin & Womersley and Siri Equations, respectively. The relationship between the NWO and the outcomes of interest, assessed using adjusted linear and logit models. The age- and sex-standardised prevalence of NWO was 18.9% (95% confidence interval (CI) 15.8, 22.2%). Comparison between normal-weight lean (normal %BF and BMI) and normal-weight obese individuals suggested no difference in systolic blood pressure (β = 2.55; 95% CI - 0.82, 5.92); however, diastolic blood pressure (β = 3.77: 95% CI 1.37, 6.18) and odds of hypertension (adjusted odds ratio (AOR) = 2.46: 95% CI 1.18, 5.13) were significantly raised in the latter. Similarly, adults with NWO had elevated blood glucose (β = 2.30; 95% CI 1.23, 15.66) and increased odds of high blood sugar level (AOR = 1.68; 95% CI 1.05, 2.67). LDL (β = 8.73: 1.56, 15.90), triglyceride (β = 20.99: 0.78, 41.22), total cholesterol (β = 10.47: 1.44, 19.50), and Cholesterol to HDL ratio (β = 0.65: 0.27, 1.04) were also raised among adults with NWO. NWO is common among adults in Addis Ababa and is associated with cardiometabolic derangements.
正常体重肥胖（NWO）-即身体质量指数（BMI）正常但体脂肪百分比（%BF）较高的个体-与心血管代谢异常的关系尚未在非洲得到探索。我们在埃塞俄比亚亚的斯亚贝巴的成年人中确定了 NWO 的流行率，并评估了其与高血压、高血糖和血脂异常之间的关联。进行了一项横断面研究，纳入了 18-64 岁的成年人（n=600）。完成了血压、血糖、血脂谱和人体测量学测量。根据皮褶厚度，使用 Durnin 和 Womersley 以及 Siri 方程分别估计体密度和 %BF。使用调整后的线性和对数模型评估 NWO 与感兴趣结局之间的关系。年龄和性别标准化的 NWO 患病率为 18.9%（95%置信区间（CI）15.8，22.2%）。与正常体重瘦（正常%BF 和 BMI）个体相比，正常体重肥胖个体的收缩压无差异（β=2.55；95%CI-0.82，5.92）；然而，舒张压（β=3.77；95%CI1.37，6.18）和高血压的比值比（AOR）明显升高（调整后的比值比（AOR）=2.46；95%CI1.18，5.13）。同样，NWO 成年人的血糖升高（β=2.30；95%CI1.23，15.66）和高血糖水平的比值比（AOR=1.68；95%CI1.05，2.67）也有所增加。LDL（β=8.73；1.56，15.90）、甘油三酯（β=20.99；0.78，41.22）、总胆固醇（β=10.47；1.44，19.50）和胆固醇与高密度脂蛋白比值（β=0.65；0.27，1.04）在 NWO 成年人中也升高。NWO 在亚的斯亚贝巴的成年人中很常见，与心血管代谢异常有关。
