Zheng Qianqian, Lin Weihua, Liu Chengguo, Zhou Yaohan, Chen Tianhui, Zhang Liqun, Zhang Xuhui, Yu Senhai, Wu Qiong, Jin Ziqi, Zhu Yimin
Department of Epidemiology & Biostatistics, School of Public Health, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Hangzhou MetaWell Technology Co., Hangzhou, China.
BMC Public Health. 2020 Apr 15;20(1):487. doi: 10.1186/s12889-020-08630-8.
There is metabolic heterogeneity in normal-weight individuals, however, there has been limited research in the Chinese population. This study aimed to investigate the prevalence, distribution and epidemiological determinants of metabolically obese but normal-weight (MONW) in a Chinese population.
A total of 17,876 normal-weight individuals were recruited from 37,815 individuals in Zhejiang province in southeastern China. Normal-weight was defined as a body mass index (BMI) of 18.5-23.9 kg/m. Metabolically abnormal traits were assessed by metabolic syndrome criteria from the International Diabetes Federation (IDF) in 2015. MONW was defined as individuals who had at least two metabolically abnormal trait but normal weight. Multiple logistic regression was used to investigate MONW risk factors, adjusting for potential confounders.
The prevalence of metabolic abnormality was 34.1% in normal-weight individuals, and the overall prevalence of MONW was 16.1% in the general population. Different MONW distributions were found between men and women depending on age. Compared with women, men had a significantly higher MONW prevalence among those aged < 45 years old, and there was a lower prevalence for those aged ≥50 years old. Higher BMI or waist circumference (WC), central obesity, menopause, and family histories of hypertension, diabetes, and cardiovascular diseases, increased MONW risk. Higher education levels, regular alcohol drinking, and balanced or vegetarian food preferences reduced MONW risk.
Normal-weight individuals have metabolic heterogeneity in China. The MONW distribution between men and women depends on age. BMI, WC, dietary factors, and family history of chronic diseases, are associated with metabolic status.
正常体重个体存在代谢异质性，然而，针对中国人群的相关研究有限。本研究旨在调查中国人群中代谢性肥胖但体重正常（MONW）的患病率、分布情况及流行病学决定因素。
从中国东南部浙江省的37815名个体中招募了总共17876名正常体重个体。正常体重定义为体重指数（BMI）为18.5 - 23.9kg/m²。采用2015年国际糖尿病联盟（IDF）的代谢综合征标准评估代谢异常特征。MONW定义为至少有两种代谢异常特征但体重正常的个体。使用多元逻辑回归研究MONW的危险因素，并对潜在混杂因素进行调整。
正常体重个体中代谢异常的患病率为34.1%，总体人群中MONW的患病率为16.1%。根据年龄，男性和女性的MONW分布不同。与女性相比，45岁以下男性的MONW患病率显著更高，50岁及以上男性的患病率较低。较高的BMI或腰围（WC）、中心性肥胖、绝经以及高血压、糖尿病和心血管疾病的家族史会增加MONW风险。较高的教育水平、经常饮酒以及均衡或素食偏好会降低MONW风险。
中国正常体重个体存在代谢异质性。男性和女性之间的MONW分布取决于年龄。BMI、WC、饮食因素以及慢性病家族史与代谢状态相关。
