Tuccinardi Dario, Conte Caterina, Lampropoulou Anastasia, Galasso Marco, Bertoccini Laura, Shang Mengyuan, Artime Esther
Department of Endocrinology and Diabetes, University Campus Bio-Medico of Rome, Rome, Italy.
Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
J Endocrinol Invest. 2025 Aug 22. doi: 10.1007/s40618-025-02693-3.
The IMPACT-O study was a multi-country, retrospective cohort study that utilized healthcare databases to describe the landscape/impact of obesity. Here, we describe the characteristics and management of adults with a first record of overweight/obesity or obesity in Italy between 2018 and 2022.
The IQVIA longitudinal patient database in Italy was used to identify individuals with a first record of overweight/obesity, as determined by diagnosis codes and/or body mass index (BMI) measurements (overweight/obesity cohort: BMI ≥ 25 kg/m; obesity cohort: BMI ≥ 30 kg/m), in the years 2018-2022. Demographic parameters, obesity-related complications (ORCs), and lifestyle, pharmacological, and surgical interventions-as recorded by general practitioners contributing to the database-were described.
The overweight/obesity cohort included 38,144 individuals, and the obesity cohort 16,489 individuals. Most individuals with overweight/obesity (72.7%) and obesity (77.1%) presented with ≥ 1 ORCs. The most frequent ORCs among people with obesity were hypertension (48.0%), dyslipidemia (26.2%), osteoarthritis (23.9%), and type 2 diabetes (14.0%). The proportion of individuals receiving pharmacological therapies with an effect on weight was ≤ 1%; there were no records of lifestyle interventions or bariatric surgery.
This analysis suggests a high rate of ORCs in people with overweight or obesity at first available record, and limited use of pharmacological treatment with an effect on weight. This highlights the need for prompt recognition and formal diagnosis of overweight and obesity in healthcare settings, accompanied by early and intensive intervention. Patient management could be improved with a systematic and centralized recording of all interventions in this population.
IMPACT - O研究是一项多国回顾性队列研究，利用医疗保健数据库来描述肥胖的情况/影响。在此，我们描述了2018年至2022年期间意大利首次记录有超重/肥胖或肥胖的成年人的特征及管理情况。
利用意大利艾昆纬纵向患者数据库，通过诊断代码和/或体重指数（BMI）测量结果（超重/肥胖队列：BMI≥25 kg/m；肥胖队列：BMI≥30 kg/m）来识别2018 - 2022年期间首次记录有超重/肥胖的个体。描述了人口统计学参数、肥胖相关并发症（ORC）以及数据库中全科医生记录的生活方式、药物和手术干预情况。
超重/肥胖队列包括38144人，肥胖队列包括16489人。大多数超重/肥胖者（72.7%）和肥胖者（77.1%）存在≥1种肥胖相关并发症。肥胖人群中最常见的肥胖相关并发症为高血压（48.0%）、血脂异常（26.2%）、骨关节炎（23.9%）和2型糖尿病（14.0%）。接受对体重有影响的药物治疗的个体比例≤1%；没有生活方式干预或减重手术的记录。
该分析表明，在首次有记录时，超重或肥胖人群中肥胖相关并发症的发生率较高，且对体重有影响的药物治疗使用有限。这凸显了在医疗环境中及时识别和正式诊断超重与肥胖并伴随早期和强化干预的必要性。通过对该人群所有干预措施进行系统和集中记录，可改善患者管理。
