Inoue Y K, Nishibe Y, Kimura T, Melnick J L
Am J Epidemiol. 1987 Mar;125(3):536-8. doi: 10.1093/oxfordjournals.aje.a114560.
Neutralizing antibodies to the Inoue-Melnick virus were detected in healthy adults in Osaka and in Houston. For adults, the prevalence rate for the cross-reacting type 3 virus was 13.8 per cent in Osaka and 29.1 per cent in Houston. Antibodies were also found in immune serum globulin prepared from American adults, but not in sera of Osaka children under 10 years of age. The Inoue-Melnick virus isolates so far obtained in Houston could be classified into three antigenic types, but in Japan all have been type 1. Type 3 antibody tests detect all homotypic infections plus about 82 per cent of type 1 infections. Thus, the actual prevalence rates for type 1 infections in Japan are somewhat higher than those found with the type 3 assay, namely, about 14 per cent for young adults and 24 per cent for those over 50 years of age. Further studies are needed to elucidate the natural history of this virus infection.
在大阪和休斯顿的健康成年人中检测到了针对井上-梅尔尼克病毒的中和抗体。对于成年人，交叉反应性3型病毒的流行率在大阪为13.8%，在休斯顿为29.1%。在美国成年人制备的免疫血清球蛋白中也发现了抗体，但在大阪10岁以下儿童的血清中未发现。到目前为止在休斯顿分离出的井上-梅尔尼克病毒可分为三种抗原类型，但在日本所有分离株均为1型。3型抗体检测可检测到所有同型感染以及约82%的1型感染。因此，日本1型感染的实际流行率略高于3型检测的结果，即年轻成年人约为14%，50岁以上人群约为24%。需要进一步研究以阐明这种病毒感染的自然史。
