Ito M
Roswell Park Cancer Institute, Buffalo, New York, USA.
J Med Virol. 1995 Sep;47(1):83-6. doi: 10.1002/jmv.1890470115.
The prevalence of antibodies to Inoue-Melnick virus (IMV) types 1 and 2 in the general population of Buffalo, New York, was studied. Serum specimens were collected from blood donors, and pediatric sera were provided from the Buffalo Children's Hospital. Neutralizing antibody titers against IMV were measured with established procedures. Very high prevalence of antibodies to both IMV types 1 and 2 were found in sera from children of Buffalo, especially in the age group 15-19 years (nearly 100%). The antibody positivity gradually decreased with advancing age, except for the groups of age 60 and older. This is in sharp contrast to a previous report examining sera from the people of Osaka, Japan, in which IMV antibody was not found in children under 10 years of age. In the group of teenagers in Buffalo, with high geometric mean antibody titers, an association with any disease was not found. The peculiar distribution of antibodies to IMV was considered to be possibly related to the high incidence of multiple sclerosis (MS) in the Buffalo area, in contrast to the data from Osaka, Japan, which is a low incidence area for MS.
对纽约州布法罗市普通人群中针对井上-梅尔尼克病毒（IMV）1型和2型的抗体流行情况进行了研究。从献血者中采集血清样本，并从布法罗儿童医院获取儿科血清。采用既定程序测量针对IMV的中和抗体滴度。在布法罗市儿童的血清中发现针对IMV 1型和2型的抗体流行率非常高，尤其是在15 - 19岁年龄组（近100%）。除60岁及以上年龄组外，抗体阳性率随年龄增长逐渐下降。这与之前一项针对日本大阪人群血清的报告形成鲜明对比，在该报告中10岁以下儿童未发现IMV抗体。在布法罗市青少年组中，几何平均抗体滴度较高，但未发现与任何疾病有关联。与日本大阪（MS低发地区）的数据相比，IMV抗体的这种特殊分布被认为可能与布法罗地区多发性硬化症（MS）的高发病率有关。
