5-氟尿嘧啶与胞苷或鸟苷联合应用对HRS-肉瘤化疗作用的增强
Potentiation of the chemotherapeutic action of 5-fluorouracil by combination with cytidine or guanosine on HRS-sarcoma.
作者信息
Osswald H, Youssef M
出版信息
J Cancer Res Clin Oncol. 1979 Apr 12;93(3):241-4. doi: 10.1007/BF00964579.
PMID:381315
Abstract
The chemotherapeutic action of 5-fluorouracil monotherapy on HRS-Sarcoma in mice was compared with those of 5-fluorouracil nucleoside combinations (thymidine, cytidine or guanosine). The curative action of 5-fluorouracil was potentiated without increasing its toxicity, when cytidine or guanosine were applied at definite intervals before or after 5-fluorouracil.
摘要
将5-氟尿嘧啶单药疗法对小鼠HRS-肉瘤的化疗作用与5-氟尿嘧啶核苷组合（胸腺嘧啶核苷、胞嘧啶核苷或鸟嘌呤核苷）的化疗作用进行了比较。当在5-氟尿嘧啶之前或之后的特定间隔应用胞嘧啶核苷或鸟嘌呤核苷时，5-氟尿嘧啶的治疗作用得到增强，而其毒性并未增加。
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