El-Sayed Mohamed Mahmoud, Mohak Sidhesh, Gala Dhir, Fabian Reka, Peterfi Zoltan, Fabian Zsolt
School of Medicine and Dentistry, Faculty of Clinical and Biomedical Sciences, University of Central Lancashire, Fylde Rd, Preston PR1 2HE, UK.
Department of Clinical Sciences, Saint James School of Medicine, Park Ridge, IL 60068, USA.
Biology (Basel). 2023 Nov 24;12(12):1463. doi: 10.3390/biology12121463.
Based on recent advances in research of chronic inflammatory conditions, there is a growing body of evidence that suggests a close correlation between the microbiota of the gastrointestinal tract and the physiologic activity of the immune system. This raises the idea that disturbances of the GI ecosystem contribute to the unfolding of chronic diseases including neurodegenerative pathologies. Here, we overview our current understanding on the putative interaction between the gut microbiota and the immune system from the aspect of multiple sclerosis, one of the autoimmune conditions accompanied by severe chronic neuroinflammation that affects millions of people worldwide.
基于慢性炎症性疾病研究的最新进展，越来越多的证据表明胃肠道微生物群与免疫系统的生理活动之间存在密切关联。这引发了一种观点，即胃肠道生态系统的紊乱会促使包括神经退行性病变在内的慢性疾病的发展。在此，我们从多发性硬化症这一自身免疫性疾病的角度，概述目前对肠道微生物群与免疫系统之间假定相互作用的理解。多发性硬化症是一种伴有严重慢性神经炎症的自身免疫性疾病，影响着全球数百万人。
