Department of Hematology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, P.R. China.
Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Cancer Med. 2024 Jan;13(1):e6856. doi: 10.1002/cam4.6856. Epub 2023 Dec 22.
Geriatric assessment can aid in optimizing treatment strategies and supportive interventions for older patients with diffuse large B-cell lymphoma (DLBCL). Fondazione Italiana Linformi has recently introduced novel geriatric assessment tools, simplified Geriatric Assessment (sGA) and Elderly Prognostic Index (EPI), aimed at tailoring the treatment and predicting the outcomes for older patients with DLBCL. The objectives of this study are the validation and possible modification of the sGA and EPI in China. In the study, both sGA and EPI demonstrated the predictive capabilities for overall survival (OS) and early mortality (both p < 0.05) in older individuals with DLBCL. Albumin, serving as an independent predictive biomarker for OS (p = 0.006), was utilized to adjust the measurements, resulting in the establishment of sGA-A and EPI-A. The sGA-A effectively addressed the shortcomings of the sGA and EPI in predicting PFS and surpassed them in predicting OS and early mortality. Nevertheless, there is insufficient evidence to support the use of sGA and EPI as treatment guidance tools. In conclusion, the modified sGA-A model proved to be a successful instrument for geriatric assessment of older patients with DLBCL.
老年评估有助于优化弥漫性大 B 细胞淋巴瘤 (DLBCL) 老年患者的治疗策略和支持性干预措施。意大利林福明基金会 (Fondazione Italiana Linformi) 最近引入了新的老年评估工具，简化的老年评估 (sGA) 和老年预后指数 (EPI)，旨在为 DLBCL 老年患者量身定制治疗方案并预测其结局。本研究旨在验证并可能修改中国的 sGA 和 EPI。在这项研究中，sGA 和 EPI 均显示出对 DLBCL 老年患者总生存 (OS) 和早期死亡率的预测能力 (均 p<0.05)。白蛋白是 OS 的独立预测生物标志物 (p=0.006)，用于调整测量值，建立了 sGA-A 和 EPI-A。sGA-A 有效地解决了 sGA 和 EPI 在预测 PFS 方面的不足，并在预测 OS 和早期死亡率方面优于它们。然而，目前尚无足够的证据支持将 sGA 和 EPI 作为治疗指导工具。总之，改良后的 sGA-A 模型被证明是评估 DLBCL 老年患者的一种成功的老年评估工具。
