Liu Danxi, He Cong, Liu Zonglin, Xu Licheng, Li Jiacheng, Zhao Zhongjie, Hu Xuewei, Chen Hua, Sun Bei, Wang Yongwei
Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Cancers (Basel). 2023 Dec 14;15(24):5842. doi: 10.3390/cancers15245842.
Cartilage intermediate layer protein 2 () facilitates interactions between matrix components in cartilage and has emerged as a potential prognostic biomarker for cancer. This study aimed to investigate the function and mechanisms of in pan-cancer. We evaluated the pan-cancer expression, methylation, and mutation data of for its clinical prognostic value. Additionally, we explored the immunological characteristics of in pan-cancer and then focused specifically on pancreatic ductal adenocarcinoma (PAAD). The subtype analysis of PAAD identified subtype-specific expression and immunological characteristics. Finally, in vitro and in vivo experiments assessed the impact of on pancreatic cancer progression. exhibited high expression in most malignancies, with significant heterogeneity in epigenetic modifications across multiple cancer types. The abnormal methylation and copy number variations in were correlated with poor prognoses. Upregulated was associated with / and more malignant subtypes. exhibited a negative correlation with immune checkpoints in PAAD, suggesting potential for immunotherapy. activated the AKT pathway, and it increased proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) in pancreatic cancer. We demonstrated that significantly contributes to pancreatic cancer progression. It serves as a prognostic biomarker and a potential target for immunotherapy.
软骨中间层蛋白2（）促进软骨中基质成分之间的相互作用，并已成为一种潜在的癌症预后生物标志物。本研究旨在探讨其在泛癌中的功能及机制。我们评估了的泛癌表达、甲基化和突变数据以了解其临床预后价值。此外，我们探索了在泛癌中的免疫特征，然后特别聚焦于胰腺导管腺癌（PAAD）。PAAD的亚型分析确定了亚型特异性表达和免疫特征。最后，体外和体内实验评估了对胰腺癌进展的影响。在大多数恶性肿瘤中呈高表达，在多种癌症类型的表观遗传修饰方面存在显著异质性。的异常甲基化和拷贝数变异与不良预后相关。上调与/以及更恶性的亚型相关。在PAAD中与免疫检查点呈负相关，提示免疫治疗潜力。激活了AKT通路，并且它增加了胰腺癌的增殖、侵袭、迁移和上皮-间质转化（EMT）。我们证明显著促进胰腺癌进展。它可作为一种预后生物标志物和免疫治疗的潜在靶点。
