人血白细胞对氯喹和羟氯喹的体外摄取：与抗风湿治疗期间细胞浓度的关系。
Uptake of chloroquine and hydroxychloroquine by human blood leucocytes in vitro: relation to cellular concentrations during antirheumatic therapy.
作者信息
French J K, Hurst N P, O'Donnell M L, Betts W H
出版信息
Ann Rheum Dis. 1987 Jan;46(1):42-5. doi: 10.1136/ard.46.1.42.
Abstract
The accumulation of chloroquine and hydroxychloroquine in unfractionated mononuclear cells and in purified monocytes, lymphocytes, and neutrophil polymorphonuclear leucocytes (PMN) was measured in vitro. Accumulation of both drugs in leucocytes was time and dose dependent. Cellular levels comparable to those found during antirheumatic therapy were achieved by preincubation for 60 minutes with up to 0.1 mM chloroquine or hydroxychloroquine.
摘要
在体外测量了氯喹和羟氯喹在未分级单核细胞以及纯化的单核细胞、淋巴细胞和中性多形核白细胞（PMN）中的蓄积情况。两种药物在白细胞中的蓄积呈时间和剂量依赖性。通过与高达0.1 mM的氯喹或羟氯喹预孵育60分钟，可达到抗风湿治疗期间所发现的细胞内水平。
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