Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
Faculty of Materials and Chemical Engineering, Yibin University, Yibin 644000, China.
Molecules. 2023 Dec 12;28(24):8043. doi: 10.3390/molecules28248043.
Two endophytic fungi (HP-3) and (HP-7) were isolated and purified from the fresh root of . Chemical investigation of the two fungi resulted in the isolation of two new phenols 2,4-dihydroxy-3-farnesyl-5-methoxy benzoic acid () and 2-hydroxyphenethyl 2-phenylacetate (), together with 22 known compounds. Their structures were elucidated by NMR, UV, IR, HRESIMS, and comparison to the literature data. Compounds and showed significant antibacterial activity against with MIC value of 6.25 μg/mL, while and displayed moderate inhibitory activities against several plant pathogenic fungi and clinically important bacterial strains. This is the first study to report the isolation, identification, and antimicrobial properties of metabolites from endophytic fungi of . Our findings may provide lead compounds for the development of new antibacterial agents.
从新鲜的当归根中分离和纯化了两种内生真菌 (HP-3) 和 (HP-7)。对这两种真菌的化学研究导致分离出两种新的酚类化合物 2,4-二羟基-3-法呢基-5-甲氧基苯甲酸 () 和 2-羟基苯乙基 2-苯乙酸酯 (), 以及 22 种已知化合物。它们的结构通过 NMR、UV、IR、HRESIMS 和与文献数据的比较来阐明。化合物 和 对 表现出显著的抗菌活性，MIC 值为 6.25 μg/mL，而 和 对几种植物病原真菌和临床上重要的细菌菌株显示出中等抑制活性。这是首次报道从当归内生真菌中分离、鉴定和抗菌代谢产物的研究。我们的发现可能为开发新的抗菌剂提供先导化合物。
