Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.
Department of Pharmacology, Medical University of Lublin, Radziwillowska 11, 20-080 Lublin, Poland.
Int J Mol Sci. 2023 Dec 7;24(24):17229. doi: 10.3390/ijms242417229.
extract is a valued plant material with known anti-inflammatory and anti-microbiological properties. Using the Design of Experiment (DoE) approach, it was possible to obtain an optimized water/alcoholic extract from , which allowed the preparation of the final material with biological activity in the wound healing process. Studies on the novel applications of in conjunction with the multifunctional chitosan carrier have been motivated by the plant's substantial pharmacological activity and the need to develop new and effective methods for the treatment of chronic wounds. The controlled release of asiaticoside was made possible by the use of chitosan as a carrier. Based on the findings of investigations using the PAMPA skin assay, which is a model imitating the permeability of actives through skin, this compound, characterized by sustained release from the chitosan delivery system, was identified as being well able to permeate biological membranes such as skin. Chitosan and the lyophilized extract of worked synergistically to block hyaluronidase, exert efficient microbiological activity and take part in the wound healing process, as proven in an in vitro model. A formulation containing 3% extract with 3% medium-molecular-weight chitosan was indicated as a potentially new treatment with high compliance and effectiveness for patients. Optimization of the chitosan-based hydrogel preparation ensured the required rheological properties necessary for the release of the bioactive from the chitosan delivery system and demonstrated a satisfactory antimicrobial activity.
提取物是一种具有已知抗炎和抗微生物特性的有价值的植物材料。通过使用实验设计（DoE）方法，可以从 中获得优化的水/醇提取物，从而可以制备具有生物活性的最终材料，用于伤口愈合过程。由于该植物具有很强的药理学活性，并且需要开发治疗慢性伤口的新的有效方法，因此激发了人们对 的新应用的研究，将其与多功能壳聚糖载体结合使用。通过使用壳聚糖作为载体，可以实现积雪草苷的控制释放。基于使用 PAMPA 皮肤测定法（一种模拟活性物质通过皮肤的渗透性的模型）进行的研究结果，该化合物具有从壳聚糖递药系统中持续释放的特点，被确定为能够很好地穿透皮肤等生物膜。壳聚糖和 的冻干提取物协同作用，抑制透明质酸酶，发挥有效的微生物学活性，并参与体外模型中的伤口愈合过程。含有 3%提取物和 3%中分子量壳聚糖的配方被认为是一种具有高顺应性和有效性的潜在新疗法，适用于患者。壳聚糖基水凝胶制剂的优化确保了从壳聚糖递药系统释放生物活性所需的流变学特性，并表现出令人满意的抗菌活性。
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