Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden.
Department of Sociology, University of Oxford, Oxford, UK.
J Psychopharmacol. 2024 Jan;38(1):110-115. doi: 10.1177/02698811231218931. Epub 2023 Dec 23.
Whereas findings from case reports and cross-sectional studies suggest that naturalistic psychedelic use may be associated with unusual visual experiences that occur after the acute pharmacological effects have subsided, such findings need to be replicated in longitudinal studies to better understand potential cause-and-effect relationships.
To investigate longitudinal associations between naturalistic psychedelic use and unusual visual experiences.
Using a longitudinal observational research design with samples representative of the US and UK adult populations with regard to sex, age, and ethnicity ( = 9732), we investigated the relationship between psychedelic use during the 2-month study period and changes in past-week unusual visual experiences.
The follow-up survey was completed by 79% of respondents ( = 7667), with 100 respondents reporting psychedelic use during the 2-month study period (1.3% of those who responded at follow-up). In covariate-adjusted regression models, the results showed that, as hypothesized, psychedelic use during the 2-month study period was associated with greater increases in unusual visual experiences. Notably, there was an interaction between lifetime psychedelic use and psychedelic use during the study period on unusual visual experiences such that those who used psychedelics for the first time reported greater increases in unusual visual experiences.
Psychedelic use may elicit unusual visual experiences that occur after the acute pharmacological effects have subsided, especially among those who have not used psychedelics previously. Future longitudinal studies are warranted to further elucidate these relationships.
尽管病例报告和横断面研究的结果表明，自然主义致幻剂的使用可能与急性药理作用消退后出现的异常视觉体验有关，但这些发现需要在纵向研究中得到复制，以便更好地理解潜在的因果关系。
调查自然主义致幻剂使用与异常视觉体验之间的纵向关联。
使用具有美国和英国成年人口代表性的纵向观察性研究设计，在性别、年龄和种族方面（ = 9732），我们调查了在研究期间的 2 个月内使用致幻剂与过去一周异常视觉体验变化之间的关系。
有 79%的受访者（ = 7667）完成了随访调查，有 100 名受访者报告在 2 个月的研究期间使用了致幻剂（占随访时回答者的 1.3%）。在调整协变量的回归模型中，结果表明，正如假设的那样，在 2 个月的研究期间使用致幻剂与异常视觉体验的增加呈正相关。值得注意的是，在一生中使用致幻剂和在研究期间使用致幻剂与异常视觉体验之间存在交互作用，即首次使用致幻剂的人报告异常视觉体验的增加更大。
致幻剂的使用可能会引起急性药理作用消退后出现异常视觉体验，尤其是在以前没有使用过致幻剂的人中。需要进行未来的纵向研究来进一步阐明这些关系。
