Cabral C M, Sen L, Palacios M F, Muchinik G, Maero E B, Scaglione C, Estevez M E
AIDS Res. 1986 Fall;2(4):335-42. doi: 10.1089/aid.1.1986.2.335.
We investigated the distribution of autologous rosette forming cells (ARFC) in the peripheral blood from subjects at risk for the acquired immunodeficiency syndrome (AIDS). The mean percentage of ARFC with autologous plasma from 35 male homosexual individuals was significantly lower than that of 31 normal controls. The mean percentage of ARFC of SARA had a direct linear correlation with the percentage of T4+ cells (p less than 0.01). Within the SARA group, those with antibodies against HTLV-III/LAV had percentages of ARFC significantly lower than SARA with negative antibodies. Plasma from SARA decreased the percentage of ARFC of normal cells when compared to normal homologous plasma (p less than 0.005), whereas normal homologous plasma did not modify the low percentage of ARFC from SARA. These results indicate that SARA possess a depletion of this subpopulation of T cells. This is more pronounced in subjects with anti-HTLV-III/LAV antibodies. The low ARFC is related to a decrease in the number of cells that correlates with the number of T4+ cells. The inhibition of normal ARFC by plasma from SARA suggests the existence of plasma factors that could mask the lymphocyte receptors for their own red blood cells and/or coat erythrocytes preventing lymphocyte-erythrocyte binding.
我们研究了获得性免疫缺陷综合征（AIDS）高危人群外周血中自体玫瑰花结形成细胞（ARFC）的分布情况。35名男性同性恋个体的ARFC与自体血浆结合的平均百分比显著低于31名正常对照者。SARA患者的ARFC平均百分比与T4 +细胞百分比呈直接线性相关（p小于0.01）。在SARA组中，抗HTLV - III/LAV抗体阳性者的ARFC百分比显著低于抗体阴性的SARA患者。与正常同源血浆相比，SARA患者的血浆降低了正常细胞的ARFC百分比（p小于0.005），而正常同源血浆并未改变SARA患者低水平的ARFC百分比。这些结果表明，SARA患者存在这种T细胞亚群的耗竭。在抗HTLV - III/LAV抗体阳性的患者中更为明显。低ARFC与细胞数量的减少有关，而细胞数量的减少与T4 +细胞数量相关。SARA患者血浆对正常ARFC的抑制作用表明存在血浆因子，这些因子可能会掩盖淋巴细胞自身红细胞的受体和/或包裹红细胞，从而阻止淋巴细胞与红细胞的结合。
