1,4 - 丁二醇和乙醇在体外大鼠脑和肝脏中竞争降解。
1,4-Butanediol and ethanol compete for degradation in rat brain and liver in vitro.
作者信息
Poldrugo F, Snead O C
出版信息
Alcohol. 1986 Nov-Dec;3(6):367-70. doi: 10.1016/0741-8329(86)90055-8.
We examined the enzymatic reaction responsible for the conversion of 1,4 butanediol to gamma-hydroxybutyric acid and the interaction of ethanol with this conversion in brain and liver. The enzyme responsible for this reaction in liver appears to be alcohol dehydrogenase. However, in both tissues, there was a competitive inhibition by ethanol of the conversion of 1,4 butanediol to gamma-hydroxybutyric acid with an apparent Ki of 6.5 X 10(-3) M in brain and 2.7 X 10(-3) M in liver. These findings may explain the potentiation of the behavioral effects of ethanol by 1,4 butanediol.
我们研究了负责将1,4 - 丁二醇转化为γ-羟基丁酸的酶促反应，以及乙醇在脑和肝脏中与这种转化的相互作用。肝脏中负责此反应的酶似乎是乙醇脱氢酶。然而，在这两种组织中，乙醇对1,4 - 丁二醇向γ-羟基丁酸转化均存在竞争性抑制，在脑中的表观抑制常数Ki为6.5×10⁻³ M，在肝脏中为2.7×10⁻³ M。这些发现可能解释了1,4 - 丁二醇对乙醇行为效应的增强作用。
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