Matsubara K, Akane A, Maseda C, Takahashi S, Fukui Y
Alcohol Drug Res. 1985;6(4):281-8.
Urine samples were collected before breakfast from 94 normal volunteers (41 males and 53 females) aged 25-70 years. Salsolinol (SA) was analyzed by gas chromatography-mass spectrometry (GC/MS), and dopamine, norepinephrine and epinephrine were determined using high performance liquid chromatography (HPLC). SA levels were significantly higher in the urine of male moderate drinkers (MDs) than in male seldom or non drinkers (SNDs). In females, however, a significant difference of urinary SA levels was not observed between MDs and SNDs. There was a sex difference of urinary SA levels among SND subjects, i.e., females showed a higher SA than males. Urinary catecholamines were not significantly altered by long-term moderate alcohol drinking in either sex. There was no correlation between urinary levels of dopamine and SA. These results indicate that urinary SA can be increased by long-term drinking even in normal, not alcoholic subjects.
从94名年龄在25至70岁之间的正常志愿者（41名男性和53名女性）中，于早餐前采集尿液样本。用气相色谱 - 质谱联用仪（GC/MS）分析去甲伪麻黄碱（SA），并使用高效液相色谱法（HPLC）测定多巴胺、去甲肾上腺素和肾上腺素。男性中度饮酒者（MDs）尿液中的SA水平显著高于男性很少饮酒或不饮酒者（SNDs）。然而，在女性中，MDs和SNDs之间未观察到尿液SA水平的显著差异。在SND受试者中存在尿液SA水平的性别差异，即女性的SA水平高于男性。长期适度饮酒对两性的尿儿茶酚胺均无显著影响。尿液中多巴胺水平与SA之间无相关性。这些结果表明，即使在正常而非酗酒的受试者中，长期饮酒也可使尿液SA增加。
