Berger M R, Petru E, Habs M, Schmähl D
Br J Cancer. 1987 Jan;55(1):37-40. doi: 10.1038/bjc.1987.8.
The administration of nicotine during the perinatal stages of life resulted in a significant decrease in tumours occurring after transplacental induction by N-methylnitrosourea (MNU). The overall tumour incidence following p.o. application of MNU to dams was 85% in rats of the F1-generation, the main occurrence being related to the neurogenic system (62% of the animals). Regular injections of nicotine before or after birth resulted in a reduction of malignancies by 17% and 22% (P = 0.08 and 0.0015), respectively. The difference in the incidence of neurogenic tumours proved to be highly significant (P less than 0.002) in rats of either sex, when nicotine was applied over 26 weeks following birth. There was a gender-specific imbalance in rats which received the carcinogen only, in favour of a lower tumour yield in females (P less than 0.04), which became less apparent when nicotine was given additionally. These findings suggest that nicotine is capable of modulating the expression of chemically induced tumours of the neurogenic system in a favourable way.
在围产期给予尼古丁，可使经胎盘注射N-甲基亚硝基脲（MNU）诱导产生的肿瘤显著减少。给母鼠经口施用MNU后，F1代大鼠的总体肿瘤发生率为85%，主要发生在神经源性系统（62%的动物）。出生前或出生后定期注射尼古丁，分别使恶性肿瘤减少了17%和22%（P = 0.08和0.0015）。当出生后26周内施用尼古丁时，无论雌雄，神经源性肿瘤的发生率差异均极显著（P < 0.002）。仅接受致癌物处理的大鼠存在性别特异性失衡，雌性大鼠的肿瘤发生率较低（P < 0.04），额外给予尼古丁后这种差异变得不那么明显。这些发现表明，尼古丁能够以一种有利的方式调节化学诱导的神经源性系统肿瘤的表达。
