Gurkalo V K, Volfson N I
Arch Geschwulstforsch. 1982;52(4):259-65.
The study of nicotine action upon N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) stomach cancer development was carried out in rats. As compared with control it was established that combined MNNG and nicotine long-term administration led to the occurrences: 1) stomach pretumorous changes of the whole mucous membrane; 2) earlier development of stomach cancer tumors and its frequency was doubled; 3) progressive decrease of acetylcholinesterase activity, especially expressed in homogenates of cerebrum hemispheres, hypothalamic region and medulla oblongata (where this activity is practically failed to be expressed). The obtained data are the witness of the nicotine ability to enhance the MNNG-stomach carcinogenesis in rats. The possible action of the autonomic nervous system in such nicotine effects is under discussion.
在大鼠中开展了尼古丁对N-甲基-N'-硝基-N-亚硝基胍（MNNG）诱发胃癌作用的研究。与对照组相比，确定MNNG与尼古丁长期联合给药会导致以下情况发生：1）整个胃黏膜出现癌前病变；2）胃癌肿瘤更早发生，其发生率翻倍；3）乙酰胆碱酯酶活性逐渐降低，在大脑半球、下丘脑区域和延髓匀浆中尤为明显（在延髓中该活性几乎未表达）。所获数据证明尼古丁有增强大鼠MNNG诱发胃癌的能力。自主神经系统在尼古丁此类作用中的可能机制正在探讨中。
